Immunobiology, volume 226, issue 5, pages 152125
NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Grebenkina P V
1
,
Salloum Zeina
1
,
Nikolaenkov Igor
2
,
Nikolaenkov Igor
,
Markova Kseniia
1
,
Markova Kseniya
,
Davidova Alina
1
,
Selkov Sergey
,
Selkov S. A.
1
,
Publication type: Journal Article
Publication date: 2021-09-01
Journal:
Immunobiology
Quartile SCImago
Q2
Quartile WOS
Q4
Impact factor: 2.8
ISSN: 01712985, 18783279
Immunology
Immunology and Allergy
Hematology
Abstract
NK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates an increase in the amount of NKp44+ NK-92 cells and in the intensity of NKp44 expression by pNK in the presence of trophoblast cells. NK-92 cell cytotoxic activity against JEG-3 cells increased only in presence of IL-18. Data on changes in the cytotoxic activity of NK-92 cells against JEG-3 cells in the presence of IL-15 and IL-18 indicate the modulation of NK cell function both by the cytokine microenvironment and directly by target cells. IL-15 and IL-18 were present in conditioned media (CM) from 1st and 3rd trimester placentas. In the presence of 1st trimester CM and JEG-3 cells, NK-92 cells showed an increase in the intensity of NKG2D expression. In the presence of 3rd trimester CM and JEG-3 cells, a decrease in the expression of NKG2D by NK-92 cells was observed. Thus, culturing of NK-92 cells with JEG-3 trophoblast cells stimulated a pronounced change in the NK cell phenotype, bringing it closer to the decidual NK cell-like phenotype.
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Citations by publishers
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1 publication, 16.67%
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1
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Mikhailova V. et al. NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells // Immunobiology. 2021. Vol. 226. No. 5. p. 152125.
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Mikhailova V., Khokhlova E., Grebenkina P. V., Salloum Z., Nikolaenkov I., Nikolaenkov I., Markova K., Markova K., Davidova A., Selkov S., Selkov S. A., Sokolov D. I. NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells // Immunobiology. 2021. Vol. 226. No. 5. p. 152125.
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TY - JOUR
DO - 10.1016/j.imbio.2021.152125
UR - https://doi.org/10.1016%2Fj.imbio.2021.152125
TI - NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
T2 - Immunobiology
AU - Mikhailova, Valentina
AU - Khokhlova, Evgeniia
AU - Grebenkina, P V
AU - Salloum, Zeina
AU - Nikolaenkov, Igor
AU - Markova, Kseniya
AU - Davidova, Alina
AU - Selkov, Sergey
AU - Sokolov, Dmitry I.
AU - Nikolaenkov, Igor
AU - Markova, Kseniia
AU - Selkov, S. A.
PY - 2021
DA - 2021/09/01 00:00:00
PB - Elsevier
SP - 152125
IS - 5
VL - 226
SN - 0171-2985
SN - 1878-3279
ER -
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@article{2021_Mikhailova,
author = {Valentina Mikhailova and Evgeniia Khokhlova and P V Grebenkina and Zeina Salloum and Igor Nikolaenkov and Kseniya Markova and Alina Davidova and Sergey Selkov and Dmitry I. Sokolov and Igor Nikolaenkov and Kseniia Markova and S. A. Selkov},
title = {NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells},
journal = {Immunobiology},
year = {2021},
volume = {226},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.imbio.2021.152125},
number = {5},
pages = {152125},
doi = {10.1016/j.imbio.2021.152125}
}
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Mikhailova, Valentina, et al. “NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells.” Immunobiology, vol. 226, no. 5, Sep. 2021, p. 152125. https://doi.org/10.1016%2Fj.imbio.2021.152125.