Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac
2
National Vaccine Institute, Postbox 457, 3720 AL, Bilthoven, The Netherlands
|
Publication type: Journal Article
Publication date: 2008-03-01
scimago Q2
wos Q2
SJR: 0.628
CiteScore: 6.4
Impact factor: 3.1
ISSN: 07317085, 1873264X
PubMed ID:
18207347
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Abstract
A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC-MS, UV and IR spectroscopy, MS-MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the CO moiety has been converted into a CS group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil.
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GOST
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Venhuis B., Zomer G., de Kaste D. Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac // Journal of Pharmaceutical and Biomedical Analysis. 2008. Vol. 46. No. 4. pp. 814-817.
GOST all authors (up to 50)
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Venhuis B., Zomer G., de Kaste D. Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac // Journal of Pharmaceutical and Biomedical Analysis. 2008. Vol. 46. No. 4. pp. 814-817.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.jpba.2007.12.007
UR - https://doi.org/10.1016/j.jpba.2007.12.007
TI - Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Venhuis, Bastiaan
AU - Zomer, G.
AU - de Kaste, D
PY - 2008
DA - 2008/03/01
PB - Elsevier
SP - 814-817
IS - 4
VL - 46
PMID - 18207347
SN - 0731-7085
SN - 1873-264X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2008_Venhuis,
author = {Bastiaan Venhuis and G. Zomer and D de Kaste},
title = {Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {2008},
volume = {46},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.jpba.2007.12.007},
number = {4},
pages = {814--817},
doi = {10.1016/j.jpba.2007.12.007}
}
Cite this
MLA
Copy
Venhuis, Bastiaan, et al. “Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac.” Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 4, Mar. 2008, pp. 814-817. https://doi.org/10.1016/j.jpba.2007.12.007.