Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement
Takahiro Doi
1
,
Kazunaga Takahashi
2
,
MIDORI YAMAZAKI
2
,
Akiko Asada
1
,
Akihiro Takeda
1
,
Kyohei Kiyota
1
,
Takaomi Tagami
1
,
Yoshiyuki Sawabe
1
,
Tetsuo Yamano
1
1
Department of Hygienic Chemistry, Osaka Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan.
|
2
Chiba Prefectural Institute of Public Health, 666-2 Nitona-cho, Chuo-ku, Chiba, Chiba 260-8715, Japan.
|
Тип публикации: Journal Article
Дата публикации: 2018-11-01
scimago Q2
wos Q2
БС1
SJR: 0.628
CiteScore: 6.4
Impact factor: 3.1
ISSN: 07317085, 1873264X
PubMed ID:
30145450
Drug Discovery
Spectroscopy
Pharmaceutical Science
Clinical Biochemistry
Analytical Chemistry
Краткое описание
A new sildenafil analog has been identified in the softgel shell of a dietary supplement. The compound was investigated by UV spectroscopy and high-resolution MS analysis, leading to the proposed structure 1-methyl-5-{5-[2-(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one. A synthetic reference compound with the proposed structure was prepared, and the two sets of analytical data were compared, confirming the structure of the new compound. The compound was named propoxyphenyl noracetildenafil from its structure and similarity with the known compound.
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ГОСТ
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Doi T. et al. Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement // Journal of Pharmaceutical and Biomedical Analysis. 2018. Vol. 161. pp. 61-65.
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Doi T., Takahashi K., YAMAZAKI M., Asada A., Takeda A., Kiyota K., Tagami T., Sawabe Y., Yamano T. Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement // Journal of Pharmaceutical and Biomedical Analysis. 2018. Vol. 161. pp. 61-65.
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TY - JOUR
DO - 10.1016/j.jpba.2018.08.031
UR - https://doi.org/10.1016/j.jpba.2018.08.031
TI - Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement
T2 - Journal of Pharmaceutical and Biomedical Analysis
AU - Doi, Takahiro
AU - Takahashi, Kazunaga
AU - YAMAZAKI, MIDORI
AU - Asada, Akiko
AU - Takeda, Akihiro
AU - Kiyota, Kyohei
AU - Tagami, Takaomi
AU - Sawabe, Yoshiyuki
AU - Yamano, Tetsuo
PY - 2018
DA - 2018/11/01
PB - Elsevier
SP - 61-65
VL - 161
PMID - 30145450
SN - 0731-7085
SN - 1873-264X
ER -
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@article{2018_Doi,
author = {Takahiro Doi and Kazunaga Takahashi and MIDORI YAMAZAKI and Akiko Asada and Akihiro Takeda and Kyohei Kiyota and Takaomi Tagami and Yoshiyuki Sawabe and Tetsuo Yamano},
title = {Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
year = {2018},
volume = {161},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.jpba.2018.08.031},
pages = {61--65},
doi = {10.1016/j.jpba.2018.08.031}
}