Open Access
Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
Mohamed El Tanani
1, 2
,
Hamdi Nsairat
2
,
Alaa A. Aljabali
3
,
Ángel Serrano-Aroca
4
,
Vijay Mishra
5
,
Yachana Mishra
6
,
Gowhar A Naikoo
7
,
Walhan Alshaer
8
,
3
5
9
Lincoln Medical School, University of Lincoln, Brayford Pool Campus, Lincoln LN6 7TS, United Kingdom
|
Publication type: Journal Article
Publication date: 2023-06-01
scimago Q1
wos Q1
SJR: 1.315
CiteScore: 10.9
Impact factor: 5.1
ISSN: 00243205, 18790631
PubMed ID:
37028545
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be required for several biological activities involving cell proliferation. The serine-threonine kinase identified as mTOR recognises PI3K-AKT stress signals. It is well established in the scientific literature that the deregulation of the mTOR pathway plays a crucial role in cancer growth and advancement. This review focuses on the normal functions of mTOR as well as its abnormal roles in cancer development.
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Metrics
19
Total citations:
19
Citations from 2024:
16
(84.21%)
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
El Tanani M. et al. Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis // Life Sciences. 2023. Vol. 323. p. 121662.
GOST all authors (up to 50)
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El Tanani M., Nsairat H., Aljabali A. A., Serrano-Aroca Á., Mishra V., Mishra Y., Naikoo G. A., Alshaer W., Tambuwala M. M. Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis // Life Sciences. 2023. Vol. 323. p. 121662.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.lfs.2023.121662
UR - https://doi.org/10.1016/j.lfs.2023.121662
TI - Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
T2 - Life Sciences
AU - El Tanani, Mohamed
AU - Nsairat, Hamdi
AU - Aljabali, Alaa A.
AU - Serrano-Aroca, Ángel
AU - Mishra, Vijay
AU - Mishra, Yachana
AU - Naikoo, Gowhar A
AU - Alshaer, Walhan
AU - Tambuwala, Murtaza M
PY - 2023
DA - 2023/06/01
PB - Elsevier
SP - 121662
VL - 323
PMID - 37028545
SN - 0024-3205
SN - 1879-0631
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_El Tanani,
author = {Mohamed El Tanani and Hamdi Nsairat and Alaa A. Aljabali and Ángel Serrano-Aroca and Vijay Mishra and Yachana Mishra and Gowhar A Naikoo and Walhan Alshaer and Murtaza M Tambuwala},
title = {Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis},
journal = {Life Sciences},
year = {2023},
volume = {323},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.lfs.2023.121662},
pages = {121662},
doi = {10.1016/j.lfs.2023.121662}
}