Mendeleev Communications

, том 28 , издание 4 , страницы 390-392

Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity

Evgeniya V Nurieva ¹

Tatyana P Trofimova ²

Alex Alexeev ¹

A.D. Proshin ³

Ekaterina A Chesnakova ⁴

Yuri Grishin ¹

Konstantin A. Lyssenko ⁵

Marina Filimonova ⁴

S. O. Bachurin ³

Olga N Zefirova ^{2, 6}

Скрыть аффилиации авторов Показать аффилиации авторов: 6 аффилиаций

Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation |

Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation |

Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation |

⁴

Medical Radiology Research Center, Russian Academy of Medical Sciences, 249036 Obninsk, Kaluga Region, Russian Federation |

⁵

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russian Federation. |

⁶

Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation |

Тип публикации: Journal Article

Дата публикации: 2018-07-01

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Mendeleev Communications

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ISSN: 09599436, 1364551X

DOI: 10.1016/j.mencom.2018.07.016

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General Chemistry

Краткое описание

In a search of nitric oxide synthase inhibitors with prolonged vasoconstrictive activity, a series of lipophilic cyclohexafused 2-amino-2-thiazolines was obtained via cyclization of tert-butyl- or benzoyl-substituted N-(cyclohex-2-en-1-yl)thioureas. The crystal structure of intermediate N-[(3aRS,7aSR)-3a,4,5,6,7,7a-hexahydro-1,3-benzothiazol-2-yl]benzamide hydrobromide was determined by X-ray analysis. One compound was found to cause pronounced and prolonged vasoconstrictive effect after single injection to the Wystar rats with lipopolysaccharide induced acute endotoxic (vasodilatation) shock.

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Nurieva E. V. et al. Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 390-392.

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Nurieva E. V., Trofimova T. P., Alexeev A., Proshin A., Chesnakova E. A., Grishin Y., Lyssenko K. A., Filimonova M., Bachurin S. O., Zefirova O. N. Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity // Mendeleev Communications. 2018. Vol. 28. No. 4. pp. 390-392.

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TY - JOUR

DO - 10.1016/j.mencom.2018.07.016

UR - https://doi.org/10.1016/j.mencom.2018.07.016

TI - Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity

T2 - Mendeleev Communications

AU - Nurieva, Evgeniya V

AU - Trofimova, Tatyana P

AU - Alexeev, Alex

AU - Proshin, A.D.

AU - Chesnakova, Ekaterina A

AU - Grishin, Yuri

AU - Lyssenko, Konstantin A.

AU - Filimonova, Marina

AU - Bachurin, S. O.

AU - Zefirova, Olga N

PY - 2018

DA - 2018/07/01

PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"

SP - 390-392

IS - 4

VL - 28

SN - 0959-9436

SN - 1364-551X

ER -

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@article{2018_Nurieva,

author = {Evgeniya V Nurieva and Tatyana P Trofimova and Alex Alexeev and A.D. Proshin and Ekaterina A Chesnakova and Yuri Grishin and Konstantin A. Lyssenko and Marina Filimonova and S. O. Bachurin and Olga N Zefirova},

title = {Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity},

journal = {Mendeleev Communications},

year = {2018},

volume = {28},

publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},

month = {jul},

url = {https://doi.org/10.1016/j.mencom.2018.07.016},

number = {4},

pages = {390--392},

doi = {10.1016/j.mencom.2018.07.016}

}

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Nurieva, Evgeniya V., et al. “Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity.” Mendeleev Communications, vol. 28, no. 4, Jul. 2018, pp. 390-392. https://doi.org/10.1016/j.mencom.2018.07.016.