volume 59 pages 333-338

Polylactide-based microspheres prepared using solid-state copolymerized chitosan and d,l-lactide.

Publication typeJournal Article
Publication date2016-03-01
SJR
CiteScore
Impact factor
ISSN09284931, 18730191
Bioengineering
Biomaterials
Mechanics of Materials
Abstract
Amphiphilic chitosan-g-poly(d,l-lactide) copolymers have been manufactured via solid-state mechanochemical copolymerization and tailored to design polyester-based microspheres for tissue engineering. A single-step solid-state reactive blending (SSRB) using low-temperature co-extrusion has been used to prepare these copolymers. These materials have been valorized to stabilize microspheres processed by an oil/water emulsion evaporation technique. Introduction of the copolymers either in water or in the oil phase of the emulsion allowed to replace a non-degradable emulsifier typically used for microparticle preparation. To enhance cell adhesion, these copolymers were also tailored to bring amino-saccharide positively charged segments to the microbead surface. Size distribution, surface morphology, and total microparticle yield have been studied and optimized as a function of the copolymer composition.
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Demina T. et al. Polylactide-based microspheres prepared using solid-state copolymerized chitosan and d,l-lactide. // Materials Science and Engineering C. 2016. Vol. 59. pp. 333-338.
GOST all authors (up to 50) Copy
Demina T., Akopova T., Vladimirov L. V., Zelenetskii A. N., Markvicheva E., Grandfils C. Polylactide-based microspheres prepared using solid-state copolymerized chitosan and d,l-lactide. // Materials Science and Engineering C. 2016. Vol. 59. pp. 333-338.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.msec.2015.09.094
UR - https://doi.org/10.1016/j.msec.2015.09.094
TI - Polylactide-based microspheres prepared using solid-state copolymerized chitosan and d,l-lactide.
T2 - Materials Science and Engineering C
AU - Demina, Tatiana
AU - Akopova, Tatiana
AU - Vladimirov, L V
AU - Zelenetskii, A N
AU - Markvicheva, E.
AU - Grandfils, Ch
PY - 2016
DA - 2016/03/01
PB - Elsevier
SP - 333-338
VL - 59
PMID - 26652381
SN - 0928-4931
SN - 1873-0191
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2016_Demina,
author = {Tatiana Demina and Tatiana Akopova and L V Vladimirov and A N Zelenetskii and E. Markvicheva and Ch Grandfils},
title = {Polylactide-based microspheres prepared using solid-state copolymerized chitosan and d,l-lactide.},
journal = {Materials Science and Engineering C},
year = {2016},
volume = {59},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.msec.2015.09.094},
pages = {333--338},
doi = {10.1016/j.msec.2015.09.094}
}