Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells
Tao Shen
1
,
Wenzhu Wan
1
,
Huiqing Yuan
2
,
Feng-Ming Kong
2
,
Huaifang Guo
1
,
Peihong Fan
1
,
Hongxiang Lou
1
Publication type: Journal Article
Publication date: 2007-05-01
scimago Q1
wos Q1
SJR: 0.726
CiteScore: 6.9
Impact factor: 3.4
ISSN: 00319422, 18733700
PubMed ID:
17343886
Biochemistry
Molecular Biology
General Medicine
Plant Science
Horticulture
Abstract
A cycloartane-type triterpenoid (1), an aliphatic alcohol glycoside (2), an eudesmane-type sesquiterpenoid (3), and a guaiane-type sesquiterpenoid (4) were isolated from the resinous exudates of Commiphora opobalsamum along with six known sesquiterpenoids (5-10). Their structures were established by extensive analysis of their 1D and 2D NMR spectroscopic data and chemical methods. The isolated compounds 1-3 and 5-9 were tested against human prostate cancer cell PC 3 and LNCaP. Among them, 1 and 2 showed moderate antiproliferative effects on human prostate cancer cell lines with IC50 values ranging from 5.7 to 23.6 microM; they were also able to inhibit the expression of androgen receptor (AR) in LNCaP cells. The six sesquiterpenoids were inactive in the bioassays.
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Total citations:
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Citations from 2024:
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GOST
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Shen T. et al. Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells // Phytochemistry. 2007. Vol. 68. No. 9. pp. 1331-1337.
GOST all authors (up to 50)
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Shen T., Wan W., Yuan H., Kong F., Guo H., Fan P., Lou H. Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells // Phytochemistry. 2007. Vol. 68. No. 9. pp. 1331-1337.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.phytochem.2007.01.013
UR - https://doi.org/10.1016/j.phytochem.2007.01.013
TI - Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells
T2 - Phytochemistry
AU - Shen, Tao
AU - Wan, Wenzhu
AU - Yuan, Huiqing
AU - Kong, Feng-Ming
AU - Guo, Huaifang
AU - Fan, Peihong
AU - Lou, Hongxiang
PY - 2007
DA - 2007/05/01
PB - Elsevier
SP - 1331-1337
IS - 9
VL - 68
PMID - 17343886
SN - 0031-9422
SN - 1873-3700
ER -
Cite this
BibTex (up to 50 authors)
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@article{2007_Shen,
author = {Tao Shen and Wenzhu Wan and Huiqing Yuan and Feng-Ming Kong and Huaifang Guo and Peihong Fan and Hongxiang Lou},
title = {Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells},
journal = {Phytochemistry},
year = {2007},
volume = {68},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.phytochem.2007.01.013},
number = {9},
pages = {1331--1337},
doi = {10.1016/j.phytochem.2007.01.013}
}
Cite this
MLA
Copy
Shen, Tao, et al. “Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells.” Phytochemistry, vol. 68, no. 9, May. 2007, pp. 1331-1337. https://doi.org/10.1016/j.phytochem.2007.01.013.