Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum
1
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29‐39 Brunswick Square, London WC1N 1AX, UK
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Publication type: Journal Article
Publication date: 2009-02-05
scimago Q1
wos Q1
SJR: 0.726
CiteScore: 6.9
Impact factor: 3.4
ISSN: 00319422, 18733700
PubMed ID:
19200564
Biochemistry
Molecular Biology
General Medicine
Plant Science
Horticulture
Abstract
In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3'')-3''-methylbutenyl-6-phenyl-pyran-2-one (2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus. Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 microg/ml, whereas compound 2 was inactive at a concentration of 512 microg/ml.
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GOST
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Shiu W. K. P., Gibbons S. Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum // Phytochemistry. 2009. Vol. 70. No. 3. pp. 403-406.
GOST all authors (up to 50)
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Shiu W. K. P., Gibbons S. Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum // Phytochemistry. 2009. Vol. 70. No. 3. pp. 403-406.
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RIS
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TY - JOUR
DO - 10.1016/j.phytochem.2008.12.016
UR - https://doi.org/10.1016/j.phytochem.2008.12.016
TI - Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum
T2 - Phytochemistry
AU - Shiu, Winnie Ka Po
AU - Gibbons, Simon
PY - 2009
DA - 2009/02/05
PB - Elsevier
SP - 403-406
IS - 3
VL - 70
PMID - 19200564
SN - 0031-9422
SN - 1873-3700
ER -
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BibTex (up to 50 authors)
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@article{2009_Shiu,
author = {Winnie Ka Po Shiu and Simon Gibbons},
title = {Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum},
journal = {Phytochemistry},
year = {2009},
volume = {70},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.phytochem.2008.12.016},
number = {3},
pages = {403--406},
doi = {10.1016/j.phytochem.2008.12.016}
}
Cite this
MLA
Copy
Shiu, Winnie Ka Po, and Simon Gibbons. “Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum.” Phytochemistry, vol. 70, no. 3, Feb. 2009, pp. 403-406. https://doi.org/10.1016/j.phytochem.2008.12.016.