Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities
Marion Girardot
1
,
Christiane Deregnaucourt
1
,
Alexandre Deville
1
,
Lionel Dubost
1
,
Roger Joyeau
1
,
Lucile Allorge
2
,
Philippe Rasoanaivo
3
,
Lengo Mambu
1
3
Institut Malgache de Recherches Appliquées, BP 3833, 101-Antananarivo, Madagascar
|
Publication type: Journal Article
Publication date: 2012-01-01
scimago Q1
wos Q1
SJR: 0.726
CiteScore: 6.9
Impact factor: 3.4
ISSN: 00319422, 18733700
PubMed ID:
22033013
Biochemistry
Molecular Biology
General Medicine
Plant Science
Horticulture
Abstract
Four vobasinyl-iboga bisindole and one 2-acyl monomeric indole alkaloids were isolated from the stem bark of Muntafara sessilifolia along with eleven known compounds. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic data including 1D and 2D NMR and mass spectrometry (MS). All isolated compounds were evaluated in vitro for antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum, and for cytotoxicity against the human lung cell line MRC-5 and the rat skeletal muscle cell line L-6. 3'-Oxo-tabernaelegantine A exhibited antiplasmodial activity (4.4 μM IC(50)) associated with non-significant cytotoxicity (selectivity index of 48). Tabernaelegantine B and D displayed the highest cytotoxicity with IC(50) values of 0.47 and 1.89 μM on MRC-5 cells, and 0.42 and 2.7 μM on L-6 cells, respectively.
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GOST
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Girardot M. et al. Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities // Phytochemistry. 2012. Vol. 73. No. 1. pp. 65-73.
GOST all authors (up to 50)
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Girardot M., Deregnaucourt C., Deville A., Dubost L., Joyeau R., Allorge L., Rasoanaivo P., Mambu L. Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities // Phytochemistry. 2012. Vol. 73. No. 1. pp. 65-73.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.phytochem.2011.09.012
UR - https://doi.org/10.1016/j.phytochem.2011.09.012
TI - Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities
T2 - Phytochemistry
AU - Girardot, Marion
AU - Deregnaucourt, Christiane
AU - Deville, Alexandre
AU - Dubost, Lionel
AU - Joyeau, Roger
AU - Allorge, Lucile
AU - Rasoanaivo, Philippe
AU - Mambu, Lengo
PY - 2012
DA - 2012/01/01
PB - Elsevier
SP - 65-73
IS - 1
VL - 73
PMID - 22033013
SN - 0031-9422
SN - 1873-3700
ER -
Cite this
BibTex (up to 50 authors)
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@article{2012_Girardot,
author = {Marion Girardot and Christiane Deregnaucourt and Alexandre Deville and Lionel Dubost and Roger Joyeau and Lucile Allorge and Philippe Rasoanaivo and Lengo Mambu},
title = {Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities},
journal = {Phytochemistry},
year = {2012},
volume = {73},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.phytochem.2011.09.012},
number = {1},
pages = {65--73},
doi = {10.1016/j.phytochem.2011.09.012}
}
Cite this
MLA
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Girardot, Marion, et al. “Indole alkaloids from Muntafara sessilifolia with antiplasmodial and cytotoxic activities.” Phytochemistry, vol. 73, no. 1, Jan. 2012, pp. 65-73. https://doi.org/10.1016/j.phytochem.2011.09.012.