Open Access
Open access
Elsevier
Stem Cell Reports
,  volume 8 ,  issue 5 ,  pages 1214-1225

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

Publication type: Journal Article
Publication date: 2017-05-09
Elsevier
scimago Q1
wos Q1
SJR: 2.314
CiteScore: 11.4
Impact factor: 5.1
ISSN: 22136711
Biochemistry
Cell Biology
Genetics
Developmental Biology
Abstract
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoretinitis (EAU). Therefore, here, we investigated the therapeutic potential of MSC-derived EVs using our established mouse models for autoimmune diseases affecting the pancreas and the eye: T1D and EAU. The data demonstrate that MSC-derived EVs effectively prevent the onset of disease in both T1D and EAU. In addition, the mixed lymphocyte reaction assay with MSC-derived EVs indicated that EVs inhibit activation of antigen-presenting cells and suppress development of T helper 1 (Th1) and Th17 cells. These results raise the possibility that MSC-derived EVs may be an alternative to cell therapy for autoimmune disease prevention.
Found 
Found 
1 citation
Kostyushev Dmitry
DSc in Biological/biomedical sciences
76 publications,  1 117 citations,  54 reviews
h-index: 18
Sechenov First Moscow State Medical University
Sechenov First Moscow State Medical University
Lomonosov Moscow State University
Lomonosov Moscow State University
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Research interests
Drug delivery
Gene editing
Infectious Diseases
Small molecules
Stem cells
1 citation
Kostyusheva Anastasiya
🥼 🤝
PhD in Biological/biomedical sciences
43 publications,  869 citations
h-index: 15
Sechenov First Moscow State Medical University
Sechenov First Moscow State Medical University
Research interests
Molecular biology
Virology
1 citation
Brezgin Sergey
🤝
PhD in Biological/biomedical sciences
51 publications,  870 citations,  1 review
h-index: 15
Sechenov First Moscow State Medical University
Sechenov First Moscow State Medical University
Sirius University of Science and Technology
Sirius University of Science and Technology
Research interests
Exosomes

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GOST |
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GOST Copy
Shigemoto Kuroda T. et al. MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis // Stem Cell Reports. 2017. Vol. 8. No. 5. pp. 1214-1225.
GOST all authors (up to 50) Copy
Shigemoto Kuroda T., KIM D. K., Jeong H. J., Park S. Y., Lee H., Park J., Kim T., An S. Y., Prockop D. J., Lee R. H. MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis // Stem Cell Reports. 2017. Vol. 8. No. 5. pp. 1214-1225.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.stemcr.2017.04.008
UR - https://doi.org/10.1016/j.stemcr.2017.04.008
TI - MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis
T2 - Stem Cell Reports
AU - Shigemoto Kuroda, Taeko
AU - KIM, DONG KI
AU - Jeong, Hyun Jeong
AU - Park, Se Yeon
AU - Lee, Hyun-Ju
AU - Park, Jong-woo
AU - Kim, Tae-Wan
AU - An, Su Yeon
AU - Prockop, Darwin J.
AU - Lee, Ryang H.
PY - 2017
DA - 2017/05/09
PB - Elsevier
SP - 1214-1225
IS - 5
VL - 8
PMID - 28494937
SN - 2213-6711
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2017_Shigemoto Kuroda,
author = {Taeko Shigemoto Kuroda and DONG KI KIM and Hyun Jeong Jeong and Se Yeon Park and Hyun-Ju Lee and Jong-woo Park and Tae-Wan Kim and Su Yeon An and Darwin J. Prockop and Ryang H. Lee},
title = {MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis},
journal = {Stem Cell Reports},
year = {2017},
volume = {8},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.stemcr.2017.04.008},
number = {5},
pages = {1214--1225},
doi = {10.1016/j.stemcr.2017.04.008}
}
MLA
Cite this
MLA Copy
Shigemoto Kuroda, Taeko, et al. “MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.” Stem Cell Reports, vol. 8, no. 5, May. 2017, pp. 1214-1225. https://doi.org/10.1016/j.stemcr.2017.04.008.