Ocular Surface

Elsevier
Elsevier
ISSN: 15420124, 19375913
SCImago
Q1
WOS
Q1
Impact factor
5.9
SJR
1.725
CiteScore
11.6
Categories
Ophthalmology
Areas
Medicine
Years of issue
2003-2025
journal names
Ocular Surface
OCUL SURF
Publications
1 724
Citations
45 402
h-index
90
Top-3 citing journals
Ocular Surface
Ocular Surface (3797 citations)
Cornea
Cornea (1537 citations)
Experimental Eye Research
Experimental Eye Research (1133 citations)
Top-3 organizations
Harvard University
Harvard University (116 publications)
University of New South Wales
University of New South Wales (67 publications)
Top-3 countries
USA (572 publications)
United Kingdom (113 publications)
Australia (92 publications)

Most cited in 5 years

Zhou L., Xu Z., Castiglione G.M., Soiberman U.S., Eberhart C.G., Duh E.J.
Ocular Surface scimago Q1 wos Q1
2020-10-01 citations by CoLab: 243 Abstract  
Conjunctival signs and symptoms are observed in a subset of patients with COVID-19, and SARS-CoV-2 has been detected in tears, raising concerns regarding the eye both as a portal of entry and carrier of the virus. The purpose of this study was to determine whether ocular surface cells possess the key factors required for cellular susceptibility to SARS-CoV-2 entry/infection. We analyzed human post-mortem eyes as well as surgical specimens for the expression of ACE2 (the receptor for SARS-CoV-2) and TMPRSS2, a cell surface-associated protease that facilitates viral entry following binding of the viral spike protein to ACE2. Across all eye specimens, immunohistochemical analysis revealed expression of ACE2 in the conjunctiva, limbus, and cornea, with especially prominent staining in the superficial conjunctival and corneal epithelial surface. Surgical conjunctival specimens also showed expression of ACE2 in the conjunctival epithelium, especially prominent in the superficial epithelium, as well as weak or focal expression in the substantia propria. All eye and conjunctival specimens also expressed TMPRSS2. Finally, Western blot analysis of protein lysates from human corneal epithelium obtained during refractive surgery confirmed expression of ACE2 and TMPRSS2. Together, these results suggest that ocular surface cells including conjunctiva are susceptible to infection by SARS-CoV-2, and could therefore serve as a portal of entry as well as a reservoir for person-to-person transmission of this virus. This highlights the importance of safety practices including face masks and ocular contact precautions in preventing the spread of COVID-19 disease.
Zhang X., Chen X., Chen L., Deng C., Zou X., Liu W., Yu H., Chen B., Sun X.
Ocular Surface scimago Q1 wos Q1
2020-07-01 citations by CoLab: 201 Abstract  
This is a cross-sectional study of patients who received a COVID-19 diagnosis between December 30, 2019 and February 7, 2020 at Tongji Hospital. A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. Patients had a mean [SD] gestational age of 57.63 [14.90] years. Of a total of 102 patients identified, 72 patients (36 men [50%] and 36 women [50%]; mean [SD] age, 58.68 [14.81] years) were confirmed to have COVID-19 by laboratory diagnosis with a SARS-CoV-2 RT-PCR assay. Only two patients (2.78%) with conjunctivitis were identified from 72 patients with a laboratory confirmed COVID-19. Of those two patients, SARS-CoV-2 RNA fragments were found in ocular discharges by SARS-CoV-2 RT-PCR in only one patient. Our findings suspect the incidence of SARS-CoV-2 infection through the ocular surface is extremely low, while the nosocomial infection of SARS-CoV-2 through the eyes after occupational exposure is a potential route. To lower the SARS-CoV-2 nosocomial infection, all health care professionals should wear protective goggles. The inefficient diagnostic method and the sampling time lag may contribute to the lower positive rate of conjunctival swab samples of SARS-CoV-2.
Collin J., Queen R., Zerti D., Bojic S., Dorgau B., Moyse N., Molina M.M., Yang C., Dey S., Reynolds G., Hussain R., Coxhead J.M., Lisgo S., Henderson D., Joseph A., et. al.
Ocular Surface scimago Q1 wos Q1
2021-07-01 citations by CoLab: 130 Abstract  
Single cell (sc) analyses of key embryonic, fetal and adult stages were performed to generate a comprehensive single cell atlas of all the corneal and adjacent conjunctival cell types from development to adulthood.Four human adult and seventeen embryonic and fetal corneas from 10 to 21 post conception week (PCW) specimens were dissociated to single cells and subjected to scRNA- and/or ATAC-Seq using the 10x Genomics platform. These were embedded using Uniform Manifold Approximation and Projection (UMAP) and clustered using Seurat graph-based clustering. Cluster identification was performed based on marker gene expression, bioinformatic data mining and immunofluorescence (IF) analysis. RNA interference, IF, colony forming efficiency and clonal assays were performed on cultured limbal epithelial cells (LECs).scRNA-Seq analysis of 21,343 cells from four adult human corneas and adjacent conjunctivas revealed the presence of 21 cell clusters, representing the progenitor and differentiated cells in all layers of cornea and conjunctiva as well as immune cells, melanocytes, fibroblasts, and blood/lymphatic vessels. A small cell cluster with high expression of limbal progenitor cell (LPC) markers was identified and shown via pseudotime analysis to give rise to five other cell types representing all the subtypes of differentiated limbal and corneal epithelial cells. A novel putative LPCs surface marker, GPHA2, expressed on the surface of 0.41% ± 0.21 of the cultured LECs, was identified, based on predominant expression in the limbal crypts of adult and developing cornea and RNAi validation in cultured LECs. Combining scRNA- and ATAC-Seq analyses, we identified multiple upstream regulators for LPCs and demonstrated a close interaction between the immune cells and limbal progenitor cells. RNA-Seq analysis indicated the loss of GPHA2 expression and acquisition of proliferative limbal basal epithelial cell markers during ex vivo LEC expansion, independently of the culture method used. Extending the single cell analyses to keratoconus, we were able to reveal activation of collagenase in the corneal stroma and a reduced pool of limbal suprabasal cells as two key changes underlying the disease phenotype. Single cell RNA-Seq of 89,897 cells obtained from embryonic and fetal cornea indicated that during development, the conjunctival epithelium is the first to be specified from the ocular surface epithelium, followed by the corneal epithelium and the establishment of LPCs, which predate the formation of limbal niche by a few weeks.Our scRNA-and ATAC-Seq data of developing and adult cornea in steady state and disease conditions provide a unique resource for defining genes/pathways that can lead to improvement in ex vivo LPCs expansion, stem cell differentiation methods and better understanding and treatment of ocular surface disorders.
Vehof J., Snieder H., Jansonius N., Hammond C.J.
Ocular Surface scimago Q1 wos Q1
2021-01-01 citations by CoLab: 122 Abstract  
To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories. A cross-sectional association study including 79,866 voluntary participants aged 20–94 years of the population-based Lifelines Cohort Study in the Netherlands. Overall, 9.1% of participants had dry eye disease as measured by the Women's Health Study dry eye questionnaire. Prevalence of dry eye symptoms were particularly prevalent in 20–30 years olds. Dry eye was associated with comorbidities in almost all body systems, including musculoskeletal, gastro-intestinal, ophthalmic, autoimmune, psychiatric, pain, functional, dermatological and atopic disorders. Numerous independent risk factors were discovered or confirmed, with strong associations for female sex, contact lens use, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, eye surgery including cataract and laser refractive surgery, keratoconus, osteoarthritis, connective tissue diseases, atherosclerosis, Graves' disease, autistic disorder, depression, ‘burnout’, Crohn's disease, sarcoid, lichen planus, rosacea, liver cirrhosis, sleep apnea, sinusitis, thyroid function, and air pollution (NO 2 ). High blood pressure and high BMI were strongly associated with less dry eye, as was current smoking, while ex-smokers had more dry eye. No clear link between dry eye and lipid or blood glucose levels was found. This study on dry eye confirmed but also refuted many risk factors from smaller epidemiological studies, and discovered numerous new risk factors in multiple etiological categories. The finding that dry eye symptoms are particularly common in young adults is concerning, and warrants further study.
Collin J., Queen R., Zerti D., Dorgau B., Georgiou M., Djidrovski I., Hussain R., Coxhead J.M., Joseph A., Rooney P., Lisgo S., Figueiredo F., Armstrong L., Lako M.
Ocular Surface scimago Q1 wos Q1
2021-01-01 citations by CoLab: 107 Abstract  
The high infection rate of SARS-CoV-2 necessitates the need for multiple studies identifying the molecular mechanisms that facilitate the viral entry and propagation. Currently the potential extra-respiratory transmission routes of SARS-CoV-2 remain unclear.Using single-cell RNA Seq and ATAC-Seq datasets and immunohistochemical analysis, we investigated SARS-CoV-2 tropism in the embryonic, fetal and adult human ocular surface.The co-expression of ACE2 receptor and entry protease TMPRSS2 was detected in the human adult conjunctival, limbal and corneal epithelium, but not in the embryonic and fetal ocular surface up to 21 post conception weeks. These expression patterns were corroborated by the single cell ATAC-Seq data, which revealed a permissive chromatin in ACE2 and TMPRSS2 loci in the adult conjunctival, limbal and corneal epithelium. Co-expression of ACE2 and TMPRSS2 was strongly detected in the superficial limbal, corneal and conjunctival epithelium, implicating these as target entry cells for SARS-CoV-2 in the ocular surface. Strikingly, we also identified the key pro-inflammatory signals TNF, NFKβ and IFNG as upstream regulators of the transcriptional profile of ACE2+TMPRSS2+ cells in the superficial conjunctival epithelium, suggesting that SARS-CoV-2 may utilise inflammatory driven upregulation of ACE2 and TMPRSS2 expression to enhance infection in ocular surface.Together our data indicate that the human ocular surface epithelium provides an additional entry portal for SARS-CoV-2, which may exploit inflammatory driven upregulation of ACE2 and TMPRSS2 entry factors to enhance infection.
Ferrari G., Rama P.
Ocular Surface scimago Q1 wos Q1
2020-07-01 citations by CoLab: 104 Abstract  
To review the literature on the etiopathogenesis of keratoconus (KC). A literature search was conducted using PUBMED and Google Scholar for keratoconus. The authors analyzed epidemiology studies, reviews, and case reports. Atopy and ocular surface inflammation are a common features of KC and should lead to a reconsideration of the traditional definition of KC as a “non inflammatory” condition. Co-morbidities suggest that KC may be the ocular manifestation of a systemic disease . Finally, KC shows higher prevalence in certain ethnicities, which calls into question the status of KC as a rare disease, at least in these communities. We believe that future studies should test whether selected, high prevalence populations exhibit specific genetic background and/or ethno-specific environmental risk factors.
Kamil S., Mohan R.R.
Ocular Surface scimago Q1 wos Q1
2021-01-01 citations by CoLab: 101 Abstract  
Corneal stromal wound healing is a complex event that occurs to restore the transparency of an injured cornea. It involves immediate apoptosis of keratocytes followed by their activation, proliferation, migration, and trans-differentiation to myofibroblasts. Myofibroblasts contract to close the wound and secrete extracellular matrix and proteinases to remodel it. Released proteinases may degenerate the basement membrane allowing an influx of cytokines from overlying epithelium. Immune cells infiltrate the wound to clear cellular debris and prevent infections. Gradually basement membrane regenerates, myofibroblasts and immune cells disappear, abnormal matrix is resorbed, and transparency of the cornea is restored. Often this cascade deregulates and corneal opacity results. Factors that prevent corneal opacity after an injury have always intrigued the researchers. They hold clinical relevance as they can guide the outcomes of corneal surgeries. Studies in the past have shed light on the role of various factors in stromal healing. TGFβ (transforming growth factor-beta) signaling is the central player guiding stromal responses. Other major regulators include myofibroblasts, basement membrane, collagen fibrils, small leucine-rich proteoglycans, biophysical cues, proteins derived from extracellular matrix, and membrane channels. The knowledge about their roles helped to develop novel therapies to prevent corneal opacity. This article reviews the role of major regulators that determine the outcome of stromal healing. It also discusses emerging therapies that modulate the role of these regulators to prevent stromal opacity.
Sawant O.B., Singh S., Wright R.E., Jones K.M., Titus M.S., Dennis E., Hicks E., Majmudar P.A., Kumar A., Mian S.I.
Ocular Surface scimago Q1 wos Q1
2021-01-01 citations by CoLab: 93 Abstract  
SARS-CoV-2 is found in conjunctival swabs and tears of COVID-19 patients. However, the presence of SARS-CoV-2 has not been detected in the human eye to date. We undertook this study to analyze the prevalence of SARS-CoV-2 in human post-mortem ocular tissues. The expression of SARS-CoV-2 RNA was assessed by RT-PCR in corneal and scleral tissues from 33 surgical-intended donors who were eliminated from a surgical use per Eye Bank Association of America (EBAA) donor screening guidelines or medical director review or positive COVID-19 test. Ocular levels of SARS-CoV-2 RNA (RT-PCR), Envelope and Spike proteins (immunohistochemistry) and anti -SARS-CoV-2 IgG and IgM antibodies (ELISA) in blood were evaluated in additional 10 research-intent COVID-19 positive donors. Of 132 ocular tissues from 33 surgical-intended donors, the positivity rate for SARS-CoV-2 RNA was ~13% (17/132). Of 10 COVID-19 donors, six had PCR positive post-mortem nasopharyngeal swabs whereas eight exhibited positive post-mortem anti -SARS-CoV-2 IgG levels. Among 20 eyes recovered from 10 COVID-19 donors: three conjunctival, one anterior corneal, five posterior corneal, and three vitreous swabs tested positive for SARS-CoV-2 RNA. SARS-CoV-2 spike and envelope proteins were detected in epithelial layer of the corneas that were procured without Povidone-Iodine (PVP–I) disinfection. Our study showed a small but noteworthy prevalence of SARS-CoV-2 in ocular tissues from COVID-19 donors. These findings underscore the criticality of donor screening guidelines, post-mortem nasopharyngeal PCR testing and PVP-I disinfection protocol to eliminate any tissue harboring SARS-CoV-2 being used for corneal transplantation.
Sharma N., Bagga B., Singhal D., Nagpal R., Kate A., Saluja G., Maharana P.K.
Ocular Surface scimago Q1 wos Q1
2022-04-01 citations by CoLab: 92 Abstract  
Infectious keratitis is a significant cause of corneal blindness worldwide. Although less prevalent in the developed world, cases of fungal keratitis account for almost half of all keratitis cases, occurring in the developing countries. These cases are one of the most refractory types of infectious keratitis and present various challenges to the treating physician such as delayed presentation, long waiting time for culture positivity, limited availability effective antifungal drugs, prolonged duration for response to therapy, a highly variable spectrum of anti-fungal drug sensitivity and a high recurrence rate following keratoplasty. The advent of rapid diagnostic tools, molecular methods, in vitro anti-fungal drug sensitivity testing, alternatives to natamycin, targeted drug delivery and most importantly the results of large randomized controlled trials have significantly improved our understanding and approach towards the diagnosis and management of cases with fungal keratitis.
Li D., Kim S., Li J., Gao Q., Choi J., Bian F., Hu J., Zhang Y., Li J., Lu R., Li Y., Pflugfelder S.C., Miao H., Chen R.
Ocular Surface scimago Q1 wos Q1
2021-04-01 citations by CoLab: 75 Abstract  
This study aimed to uncover novel cell types in heterogenous basal limbus of human cornea for identifying LSC at single cell resolution.Single cells of human limbal basal epithelium were isolated from young donor corneas. Single-cell RNA-Sequencing was performed using 10x Genomics platform, followed by clustering cell types through the graph-based visualization method UMAP and unbiased computational informatic analysis. Tissue RNA in situ hybridization with RNAscope, immunofluorescent staining and multiple functional assays were performed using human corneas and limbal epithelial culture models.Single-cell transcriptomics of 16,360 limbal basal cells revealed 12 cell clusters belonging to three lineages. A smallest cluster (0.4% of total cells) was identified as LSCs based on their quiescent and undifferentiated states with enriched marker genes for putative epithelial stem cells. TSPAN7 and SOX17 are discovered and validated as new LSC markers based on their exclusive expression pattern and spatial localization in limbal basal epithelium by RNAscope and immunostaining, and functional role in cell growth and tissue regeneration models with RNA interference in cultures. Interestingly, five cell types/states mapping a developmental trajectory of LSC from quiescence to proliferation and differentiation are uncovered by Monocle3 and CytoTRACE pseudotime analysis. The transcription factor networks linking novel signaling pathways are revealed to maintain LSC stemness.This human corneal scRNA-Seq identifies the LSC population and uncovers novel cell types mapping the differentiation trajectory in heterogenous limbal basal epithelium. The findings provide insight into LSC concept and lay the foundation for understanding the corneal homeostasis and diseases.
from 3 chars
Publications found: 1732
Assessment of the Clonal Growth Potential of Meibomian Gland Stem/Progenitor Cells via Clonal Analysis
Guo Y., Zhang R., Zhang M., Luo S., Li W., Sun L., Zhong M., Liu Z., Wu Y., Li W., Bu J.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Impact of botulinum toxin type A on ocular pain with neuropathic features
Locatelli E.V., Huang J.J., Betz J.D., Huang J.J., Kantor N.B., Reyes N., Felix E.R., Lee W.W., Galor A.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
The impact of dry eye disease on patient-reported quality of life: a Save Sight Dry Eye Registry study
Kandel H., Stapleton AO F., Downie L.E., Chidi‐Egboka N., Botin D.M., Arnalich-Montiel F., Rauz S., Recchioni A., Sitaula S., Markoulli M., Daien V., Babeau F., Geerling G., Craig J.P., Watson OAM S.L.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells
Lapajne L., Lakk M., Rudzitis C.N., Vemaraju S., Lang R.A., Hawlina M., Križaj D.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
The role of lysophosphatidic acid and its receptors in corneal nerve regeneration
Kheyrollah M., Brandt N., Bräuer A.U., Schrader S., Mertsch S.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Severe corneal manifestations of graft-versus-host disease: experience of a tertiary referral center
A B., V G., S D., PH P., E K., D M., G S., R P.D., EE G.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Systems Biology of Dry Eye: Unraveling Molecular Mechanisms through Multi-Omics Integration
Zhang Z., Liu C., Zhao L., Yao J.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Mechanoreceptor Piezo1 channel-Mediated Interleukin Expression in Conjunctival Epithelial Cells: Linking Mechanical Stress to Ocular Inflammation
Fukuoka S., Adachi N., Ouchi E., Ikemoto H., Okumo T., Ishikawa F., Onda H., Sunagawa M.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Differential homing of monocytes and neutrophils in the epithelial layer of HSV-1 infected cornea regulates viral dissemination and wound healing
Setia M., Suvas P.K., Rana M., Chakraborty A., Suvas S.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Destructive and Protective Effects and Therapeutic Targets of IL-36 Family Cytokines in Dry Eye Disease
Chen X., Lin N., Liu H., Lin J., Gao N., Liu Z., de Paiva C.S., Pflugfelder S.C., Li D.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
A novel Schirmer Strip-Based Tear Matrix Metalloproteinase Measurement in Dry Eye Evaluation
Chen D., Wubi Li A.P., Yang S., Song H., Di Y., Zhong W., Zhang M., Long Q., Li Y., Zhao C.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium
Lian L., Ye X., Wang Z., Li J., Wang J., Chen L., Reinach P.S., Ma X., Chen W., Zheng Q.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
A Prospective Self-Controlled Study on the Alterations of the Ocular Surface and Conjunctival Transcriptomic Profile Associated with Prolonged Exposure to Video Display Terminals
Li L., Zhu X., Xu W., Dai M., Liu Z., Li Y., Fang Y., Li J., Chen W.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0
Prevalence of dry eye disease in Spain: a population-based survey (PrevEOS)
Benítez-del-Castillo J.M., Burgos B.
Q1
Elsevier
Ocular Surface 2025 citations by CoLab: 0

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USA, 572, 33.18%
United Kingdom, 113, 6.55%
Australia, 92, 5.34%
China, 84, 4.87%
Japan, 82, 4.76%
Spain, 76, 4.41%
India, 70, 4.06%
Germany, 60, 3.48%
Italy, 51, 2.96%
Canada, 48, 2.78%
New Zealand, 39, 2.26%
Singapore, 38, 2.2%
France, 36, 2.09%
Republic of Korea, 34, 1.97%
Brazil, 31, 1.8%
Norway, 31, 1.8%
Netherlands, 21, 1.22%
Iran, 19, 1.1%
Turkey, 14, 0.81%
Sweden, 13, 0.75%
Egypt, 11, 0.64%
Switzerland, 10, 0.58%
Denmark, 9, 0.52%
Israel, 9, 0.52%
Poland, 9, 0.52%
Thailand, 8, 0.46%
Mexico, 7, 0.41%
Greece, 6, 0.35%
Chile, 6, 0.35%
Bulgaria, 5, 0.29%
Hungary, 5, 0.29%
Ireland, 5, 0.29%
Finland, 5, 0.29%
Austria, 3, 0.17%
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Ghana, 3, 0.17%
Iraq, 3, 0.17%
Colombia, 3, 0.17%
Portugal, 2, 0.12%
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Vietnam, 2, 0.12%
Nigeria, 2, 0.12%
UAE, 2, 0.12%
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Romania, 1, 0.06%
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Tanzania, 1, 0.06%
Uganda, 1, 0.06%
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China, 56, 8.92%
United Kingdom, 50, 7.96%
India, 46, 7.32%
Australia, 41, 6.53%
Japan, 34, 5.41%
Norway, 29, 4.62%
Canada, 27, 4.3%
Germany, 25, 3.98%
Italy, 25, 3.98%
New Zealand, 25, 3.98%
Republic of Korea, 19, 3.03%
Spain, 18, 2.87%
France, 17, 2.71%
Netherlands, 17, 2.71%
Brazil, 15, 2.39%
Singapore, 13, 2.07%
Iran, 10, 1.59%
Denmark, 9, 1.43%
Egypt, 8, 1.27%
Israel, 8, 1.27%
Switzerland, 8, 1.27%
Sweden, 8, 1.27%
Thailand, 7, 1.11%
Mexico, 6, 0.96%
Poland, 6, 0.96%
Turkey, 5, 0.8%
Ireland, 4, 0.64%
Hungary, 3, 0.48%
Colombia, 3, 0.48%
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Uganda, 1, 0.16%
Finland, 1, 0.16%
Croatia, 1, 0.16%
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