Open Access

Stem Cell Reports

, volume 16 , issue 5 , pages 1031-1038

Opportunities and challenges with stem cell-based embryo models

Kristie Nybo ¹

Patrick Tam ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Hospital for Sick Children, University of Toronto, and The Gairdner Foundation, Toronto, Canada

University of Toronto

Hospital for Sick Children

Children's Medical Research Institute, University of Sydney, and School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia |

Publication type: Journal Article

Publication date: 2021-05-01

Elsevier

Stem Cell Reports

scimago Q1

wos Q1

SJR: 2.314

CiteScore: 11.4

Impact factor: 5.1

ISSN: 22136711

DOI: 10.1016/j.stemcr.2021.02.002

Copy DOI

PubMed ID: 33667412

Biochemistry

Cell Biology

Genetics

Developmental Biology

Abstract

Stem cell-based embryo models open an unprecedented avenue for modeling embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in mammalian development. Experimentation on these embryo models can lead to a better understanding of the mechanisms of development and offers opportunities for functional genomic studies of disease-causing mechanisms, identification of therapeutic targets, and preclinical modeling of advanced therapeutics for precision medicine. An immediate challenge is to create embryo models of high fidelity to embryogenesis and organogenesis in vivo, to ensure that the knowledge gleaned is biologically meaningful and clinically relevant.

Found

1 citation

Yanagida Ayaka

35 publications, 1 731 citations

h-index: 15

University of Tokyo

University of Cambridge

Tokyo Medical and Dental University

Research interests

Developmental biology

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GOST |

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GOST Copy

Nybo K., Tam P. Opportunities and challenges with stem cell-based embryo models // Stem Cell Reports. 2021. Vol. 16. No. 5. pp. 1031-1038.

GOST all authors (up to 50) Copy

Nybo K., Tam P. Opportunities and challenges with stem cell-based embryo models // Stem Cell Reports. 2021. Vol. 16. No. 5. pp. 1031-1038.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.stemcr.2021.02.002

UR - https://doi.org/10.1016/j.stemcr.2021.02.002

TI - Opportunities and challenges with stem cell-based embryo models

T2 - Stem Cell Reports

AU - Nybo, Kristie

AU - Tam, Patrick

PY - 2021

DA - 2021/05/01

PB - Elsevier

SP - 1031-1038

IS - 5

VL - 16

PMID - 33667412

SN - 2213-6711

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Nybo,

author = {Kristie Nybo and Patrick Tam},

title = {Opportunities and challenges with stem cell-based embryo models},

journal = {Stem Cell Reports},

year = {2021},

volume = {16},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016/j.stemcr.2021.02.002},

number = {5},

pages = {1031--1038},

doi = {10.1016/j.stemcr.2021.02.002}

}

MLA

Cite this

MLA Copy

Nybo, Kristie, and Patrick Tam. “Opportunities and challenges with stem cell-based embryo models.” Stem Cell Reports, vol. 16, no. 5, May. 2021, pp. 1031-1038. https://doi.org/10.1016/j.stemcr.2021.02.002.

Publisher

Elsevier

Journal

Stem Cell Reports

scimago Q1

wos Q1

SJR

2.314

CiteScore

11.4

Impact factor

5.1

ISSN

22136711 (Print, Electronic)