Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin
Publication type: Journal Article
Publication date: 2011-02-01
scimago Q2
wos Q3
SJR: 0.620
CiteScore: 4.3
Impact factor: 2.3
ISSN: 0039128X, 18785867
PubMed ID:
20951717
Organic Chemistry
Biochemistry
Molecular Biology
Pharmacology
Clinical Biochemistry
Endocrinology
Abstract
New symmetrical bis-steroidal pyrazine dimers that are cephalostatins/ritterazines analogues have been prepared easily from a cheap, readily available natural steroid (diosgenin). These dimers were obtained by classical, condensation of α-amino ketones in order to construct the pyrazine rings. The three dimers differ in the functionalized diosgenin: (25R)-5α,6β-dihydroxy-5α-spirosta-3-one, (25R)-4,5α-epoxy-5β-spirosta-3,6-dione and (25R)-5α-hydroxy-5α-spirosta-3,6-dione respectively.
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Metrics
15
Total citations:
15
Citations from 2024:
1
(6.67%)
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GOST
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Shawakfeh K. Q., Al Said N. H. Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin // Steroids. 2011. Vol. 76. No. 3. pp. 232-237.
GOST all authors (up to 50)
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Shawakfeh K. Q., Al Said N. H. Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin // Steroids. 2011. Vol. 76. No. 3. pp. 232-237.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.steroids.2010.10.002
UR - https://doi.org/10.1016/j.steroids.2010.10.002
TI - Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin
T2 - Steroids
AU - Shawakfeh, Khaled Q.
AU - Al Said, Naim H
PY - 2011
DA - 2011/02/01
PB - Elsevier
SP - 232-237
IS - 3
VL - 76
PMID - 20951717
SN - 0039-128X
SN - 1878-5867
ER -
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BibTex (up to 50 authors)
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@article{2011_Shawakfeh,
author = {Khaled Q. Shawakfeh and Naim H Al Said},
title = {Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin},
journal = {Steroids},
year = {2011},
volume = {76},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.steroids.2010.10.002},
number = {3},
pages = {232--237},
doi = {10.1016/j.steroids.2010.10.002}
}
Cite this
MLA
Copy
Shawakfeh, Khaled Q., and Naim H Al Said. “Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin.” Steroids, vol. 76, no. 3, Feb. 2011, pp. 232-237. https://doi.org/10.1016/j.steroids.2010.10.002.