Increased hepatic gluconeogenesis and type 2 diabetes mellitus
Emma Barroso
1, 2, 3, 4
,
Javier Jurado-Aguilar
1, 2, 3, 4
,
W Wahli
5, 6, 7
,
Xavier Palomer
1, 2, 3, 4
,
Manuel Vázquez-Carrera
1, 2, 3, 4
4
7
ToxAlim (Research Center in Food Toxicology), INRAE, UMR1331, F-31300 Toulouse Cedex, France
|
Publication type: Journal Article
Publication date: 2024-12-01
scimago Q1
wos Q1
SJR: 3.485
CiteScore: 21.2
Impact factor: 12.6
ISSN: 10432760, 18793061
PubMed ID:
38816269
Abstract
Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance. Metformin, the most prescribed drug for the treatment of T2DM, is believed to exert its effect mainly by reducing hepatic gluconeogenesis. Here, we discuss how increased hepatic gluconeogenesis contributes to T2DM and we review newly revealed mechanisms underlying the attenuation of gluconeogenesis by metformin. In addition, we analyze the recent findings on new determinants involved in the regulation of gluconeogenesis, which might ultimately lead to the identification of novel and targeted treatment strategies for T2DM.
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Metrics
34
Total citations:
34
Citations from 2024:
33
(97.06%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Barroso E. et al. Increased hepatic gluconeogenesis and type 2 diabetes mellitus // Trends in Endocrinology and Metabolism. 2024. Vol. 35. No. 12. pp. 1062-1077.
GOST all authors (up to 50)
Copy
Barroso E., Jurado-Aguilar J., Wahli W., Palomer X., Vázquez-Carrera M. Increased hepatic gluconeogenesis and type 2 diabetes mellitus // Trends in Endocrinology and Metabolism. 2024. Vol. 35. No. 12. pp. 1062-1077.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tem.2024.05.006
UR - https://linkinghub.elsevier.com/retrieve/pii/S1043276024001243
TI - Increased hepatic gluconeogenesis and type 2 diabetes mellitus
T2 - Trends in Endocrinology and Metabolism
AU - Barroso, Emma
AU - Jurado-Aguilar, Javier
AU - Wahli, W
AU - Palomer, Xavier
AU - Vázquez-Carrera, Manuel
PY - 2024
DA - 2024/12/01
PB - Elsevier
SP - 1062-1077
IS - 12
VL - 35
PMID - 38816269
SN - 1043-2760
SN - 1879-3061
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Barroso,
author = {Emma Barroso and Javier Jurado-Aguilar and W Wahli and Xavier Palomer and Manuel Vázquez-Carrera},
title = {Increased hepatic gluconeogenesis and type 2 diabetes mellitus},
journal = {Trends in Endocrinology and Metabolism},
year = {2024},
volume = {35},
publisher = {Elsevier},
month = {dec},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1043276024001243},
number = {12},
pages = {1062--1077},
doi = {10.1016/j.tem.2024.05.006}
}
Cite this
MLA
Copy
Barroso, Emma, et al. “Increased hepatic gluconeogenesis and type 2 diabetes mellitus.” Trends in Endocrinology and Metabolism, vol. 35, no. 12, Dec. 2024, pp. 1062-1077. https://linkinghub.elsevier.com/retrieve/pii/S1043276024001243.