Enaminones as building blocks in drug development: Recent advances in their chemistry, synthesis, and biological properties
Isis J Amaye
1
,
Rhashanda D Haywood
1
,
Edelquine M Mandzo
2
,
Jeremy J Wirick
2
,
Patrice L Jackson Ayotunde
1
Publication type: Journal Article
Publication date: 2021-03-01
scimago Q3
wos Q2
SJR: 0.426
CiteScore: 4.1
Impact factor: 2.2
ISSN: 00404020, 14645416
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
The enaminone scaffold is a versatile building block used in organic synthesis. The amine – alkene – carbonyl conjugated system, having both nucleophilic and electrophilic characteristics, allows for a highly reactive center, that can serve as a pharmacophore for molecules in drug development. Analogs with this moiety have an array of pharmacological responses such as antiviral, anti-inflammatory, antitumor, anticancer and anticonvulsant activities. Herein, this review provides insight of current synthetic methodologies that employ enaminones as intermediates and their preparations. Structure activity relationship studies of various enaminone analogs will be examined in this review as well.
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107
Total citations:
107
Citations from 2024:
66
(62.27%)
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GOST
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Amaye I. J. et al. Enaminones as building blocks in drug development: Recent advances in their chemistry, synthesis, and biological properties // Tetrahedron. 2021. Vol. 83. p. 131984.
GOST all authors (up to 50)
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Amaye I. J., Haywood R. D., Mandzo E. M., Wirick J. J., Jackson Ayotunde P. L. Enaminones as building blocks in drug development: Recent advances in their chemistry, synthesis, and biological properties // Tetrahedron. 2021. Vol. 83. p. 131984.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tet.2021.131984
UR - https://doi.org/10.1016/j.tet.2021.131984
TI - Enaminones as building blocks in drug development: Recent advances in their chemistry, synthesis, and biological properties
T2 - Tetrahedron
AU - Amaye, Isis J
AU - Haywood, Rhashanda D
AU - Mandzo, Edelquine M
AU - Wirick, Jeremy J
AU - Jackson Ayotunde, Patrice L
PY - 2021
DA - 2021/03/01
PB - Elsevier
SP - 131984
VL - 83
SN - 0040-4020
SN - 1464-5416
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Amaye,
author = {Isis J Amaye and Rhashanda D Haywood and Edelquine M Mandzo and Jeremy J Wirick and Patrice L Jackson Ayotunde},
title = {Enaminones as building blocks in drug development: Recent advances in their chemistry, synthesis, and biological properties},
journal = {Tetrahedron},
year = {2021},
volume = {83},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.tet.2021.131984},
pages = {131984},
doi = {10.1016/j.tet.2021.131984}
}