Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
Wataru FUJII
1
,
Kazuya Toda
2
,
Kiriko Matsumoto
2
,
Koichiro Kawaguchi
2
,
Seiichi Kawahara
3
,
Yasunao Hattori
4
,
Hiroshi FUJII
2
,
Hidefumi Makabe
1
3
St. Cousair Co., Ltd, 1260 Imogawa, Kami-minochi, Nagano 389-1201, Japan
|
Publication type: Journal Article
Publication date: 2013-12-01
scimago Q3
wos Q3
SJR: 0.334
CiteScore: 3.2
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Total synthesis of prodelphinidin B1, B2, and B4 has been accomplished. The key step is Lewis acid-mediated equimolar condensations between an epigallocatechin and/or a gallocatechin nucleophile and an epigallocatechin and/or a gallocatechin electrophile. The antitumor effects of synthetic prodelphinidin B1–B4 against human PC-3 prostate cancer cell lines have been investigated. These compounds showed significant antitumor effects. Their activity seemed to be little bit stronger than EGCG and prodelphinidin B3, known antitumor agent.
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GOST
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FUJII W. et al. Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines // Tetrahedron Letters. 2013. Vol. 54. No. 52. pp. 7188-7192.
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FUJII W., Toda K., Matsumoto K., Kawaguchi K., Kawahara S., Hattori Y., FUJII H., Makabe H. Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines // Tetrahedron Letters. 2013. Vol. 54. No. 52. pp. 7188-7192.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.tetlet.2013.10.113
UR - https://doi.org/10.1016/j.tetlet.2013.10.113
TI - Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
T2 - Tetrahedron Letters
AU - FUJII, Wataru
AU - Toda, Kazuya
AU - Matsumoto, Kiriko
AU - Kawaguchi, Koichiro
AU - Kawahara, Seiichi
AU - Hattori, Yasunao
AU - FUJII, Hiroshi
AU - Makabe, Hidefumi
PY - 2013
DA - 2013/12/01
PB - Elsevier
SP - 7188-7192
IS - 52
VL - 54
SN - 0040-4039
SN - 1873-3581
ER -
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BibTex (up to 50 authors)
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@article{2013_FUJII,
author = {Wataru FUJII and Kazuya Toda and Kiriko Matsumoto and Koichiro Kawaguchi and Seiichi Kawahara and Yasunao Hattori and Hiroshi FUJII and Hidefumi Makabe},
title = {Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines},
journal = {Tetrahedron Letters},
year = {2013},
volume = {54},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.tetlet.2013.10.113},
number = {52},
pages = {7188--7192},
doi = {10.1016/j.tetlet.2013.10.113}
}
Cite this
MLA
Copy
FUJII, Wataru, et al. “Syntheses of prodelphinidin B1, B2, and B4 and their antitumor activities against human PC-3 prostate cancer cell lines.” Tetrahedron Letters, vol. 54, no. 52, Dec. 2013, pp. 7188-7192. https://doi.org/10.1016/j.tetlet.2013.10.113.