Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells
Shuqiang Liu
1
,
Dan Wang
2
,
Junwen Zhang
1
,
Dong-Zhi Zhang
1
,
Meng Gong
1
,
Chao Wang
1
,
Ning Wei
1
,
Wenhua Liu
3
,
Martin Oberlack
3
,
Chongxue Zhao
4
,
Yaxiong Cui
4
,
Defu Hu
1
2
Food Service, Qingdao Entry-Exit Inspection and Quarantine Bureau, Qingdao 266000, People’s Republic of China
|
3
Shanxi Institute of Zoology, Xi′an 710032, People’s Republic of China
|
4
The Endangered Animal Rescue Centre of Wuwei 733300, People’s Republic of China
|
Тип публикации: Journal Article
Дата публикации: 2012-09-01
scimago Q2
wos Q3
БС1
SJR: 0.718
CiteScore: 5.5
Impact factor: 2.7
ISSN: 08872333, 18793177
PubMed ID:
22564900
General Medicine
Toxicology
Краткое описание
A previous study has shown that CTN (Citrinin) inhibits mouse testosterone production. In this study, the mechanism by which testosterone production is inhibited by CTN in rat Leydig cells was investigated, and the morphological evidence of apoptosis, including nuclei fragmentation and phosphatidylserine (PS) exposure on cell surfaces, was clearly observed 36h after CTN exposure. The results showed that citrinin at 50 and 100μM significantly suppressed testosterone secretion by human chorionic gonadotropin (hCG) at 10IU/ml. Western blotting results showed that CTN induced formation of processed p53, caspase-9, and caspase-3 proteins in a dose-dependent manner; CTN also induced a dose-dependent increase in caspase-3 catalytic activity. Western blot assays also showed that CTN decreased expression of three key enzymes (P450scc, 3β-HSD-1, and StAR) of testosterone production. Taken together, these results suggested that CTN reduced testosterone secretion by inducing apoptosis in rat Leydig cells, a mechanism that might account for CTN stimulation of p53 expression followed by activation of multiple caspases.
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ГОСТ
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Liu S. et al. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells // Toxicology in Vitro. 2012. Vol. 26. No. 6. pp. 856-861.
ГОСТ со всеми авторами (до 50)
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Liu S., Wang D., Zhang J., Zhang D., Gong M., Wang C., Wei N., Liu W., Oberlack M., Zhao C., Cui Y., Hu D. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells // Toxicology in Vitro. 2012. Vol. 26. No. 6. pp. 856-861.
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TY - JOUR
DO - 10.1016/j.tiv.2012.04.026
UR - https://doi.org/10.1016/j.tiv.2012.04.026
TI - Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells
T2 - Toxicology in Vitro
AU - Liu, Shuqiang
AU - Wang, Dan
AU - Zhang, Junwen
AU - Zhang, Dong-Zhi
AU - Gong, Meng
AU - Wang, Chao
AU - Wei, Ning
AU - Liu, Wenhua
AU - Oberlack, Martin
AU - Zhao, Chongxue
AU - Cui, Yaxiong
AU - Hu, Defu
PY - 2012
DA - 2012/09/01
PB - Elsevier
SP - 856-861
IS - 6
VL - 26
PMID - 22564900
SN - 0887-2333
SN - 1879-3177
ER -
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@article{2012_Liu,
author = {Shuqiang Liu and Dan Wang and Junwen Zhang and Dong-Zhi Zhang and Meng Gong and Chao Wang and Ning Wei and Wenhua Liu and Martin Oberlack and Chongxue Zhao and Yaxiong Cui and Defu Hu},
title = {Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells},
journal = {Toxicology in Vitro},
year = {2012},
volume = {26},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.tiv.2012.04.026},
number = {6},
pages = {856--861},
doi = {10.1016/j.tiv.2012.04.026}
}
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MLA
Скопировать
Liu, Shuqiang, et al. “Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells.” Toxicology in Vitro, vol. 26, no. 6, Sep. 2012, pp. 856-861. https://doi.org/10.1016/j.tiv.2012.04.026.