Nanotechnology-assisted microfluidic systems for chemical sensing, biosensing, and bioanalysis

Microfluidics technology holds a special place in the field of biomedical and analytical chemistry thanks to its properties, such as low consumption of reagent, quick analysis time, and ease of integration. Nanotechnology makes significant progress towards high sensitive and selective detection of analytes. Compared to bulk materials, nanomaterials have distinctive properties which motivate the combination of nanoparticles with biosensors. Nanoparticle-based biosensors can bring a series of advantages in advancement high-throughput and ultrasensitive detection. In recent years, numerous studies have been done on the integration of nanomaterials with microfluidic systems. Given the scope of the nanoparticle-integrated biosensors, the purpose of this review is to provide an overview of various types of nanoparticle-integrated microfluidic biosensors. It mainly focuses on developed microfluidics-based on gold nanoparticles, graphene oxide , quantum dots, magnetic nanoparticles, carbon dots, silica nanoparticles, zinc oxide, and nanocomposites. This review summarizes the latest advancement of nanotechnology-assisted microfluidic biosensing on a smartphone for biochemical analysis. Also, the role of nanomaterials on the detection methods such as electrochemical, photoelectrochemical, electrochemiluminescent, optical piezoelectric, and so on was surveyed. In our opinion, the cooperation of microfluidic biodevices and nanoparticles is very beneficial and is expected to be effective in addressing the challenges related to microfluidic systems. • Recent advances and limitations in nanotechnology-assisted microfluidic biosensing were discussed. • The analytical figures of merit of the developed methods are also evaluated. • Current improvements on the monitoring of biomarkers using microfluidic strategies were investigated.