Journal of Molecular and Cellular Cardiology, volume 114, pages 211-219
Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves
Kostina A.A.
1, 2
,
Shishkova A
3
,
Игнатьева Е.В.
3
,
Irtyuga O.
3
,
Bogdanova M.
4
,
Levchuk K.
3
,
Golovkin Alexey
3
,
Zhiduleva E
3
,
Uspenskiy Vladimir
3
,
Moiseeva O.
3
,
Faggian Giuseppe
5, 6
,
Vaage Jarle
1, 7
,
Kostareva Anna
1
,
Rutkovskiy A
4, 7
,
Malashicheva Anna В.
1, 8
6
Verona Italy
|
Publication type: Journal Article
Publication date: 2018-01-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5
ISSN: 00222828, 10958584
Molecular Biology
Cardiology and Cardiovascular Medicine
Abstract
Calcific aortic valve disease is the most common heart valve disease in the Western world. Bicuspid and tricuspid aortic valve calcifications are traditionally considered together although the dynamics of the disease progression is different between the two groups of patients. Notch signaling is critical for bicuspid valve development and NOTCH1 mutations are associated with bicuspid valve and calcification. We hypothesized that Notch-dependent mechanisms of valve mineralization might be different in the two groups.We used aortic valve interstitial cells and valve endothelial cells from patients with calcific aortic stenosis with bicuspid or tricuspid aortic valve. Expression of Notch-related genes in valve interstitial cells by qPCR was different between bicuspid and tricuspid groups. Discriminant analysis of gene expression pattern in the interstitial cells revealed that the cells from calcified bicuspid valves formed a separate group from calcified tricuspid and control cells. Interstitial cells from bicuspid calcified valves demonstrated significantly higher sensitivity to stimuli at early stages of induced proosteogenic differentiation and were significantly more sensitive to the activation of proosteogenic OPN, ALP and POSTIN expression by Notch activation. Notch-activated endothelial-to-mesenchymal transition and the corresponding expression of HEY1 and SLUG were also more prominent in bicuspid valve derived endothelial cells compared to the cells from calcified tricuspid and healthy valves.Early signaling events including Notch-dependent mechanisms that are responsible for the initiation of aortic valve calcification are different between the patients with bicuspid and tricuspid aortic valves.
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Kostina A. et al. Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves // Journal of Molecular and Cellular Cardiology. 2018. Vol. 114. pp. 211-219.
GOST all authors (up to 50)
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Kostina A., Shishkova A., Игнатьева Е., Irtyuga O., Bogdanova M., Levchuk K., Golovkin A., Zhiduleva E., Uspenskiy V., Moiseeva O., Faggian G., Vaage J., Kostareva A., Rutkovskiy A., Malashicheva A. В. Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves // Journal of Molecular and Cellular Cardiology. 2018. Vol. 114. pp. 211-219.
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TY - JOUR
DO - 10.1016/j.yjmcc.2017.11.009
UR - https://doi.org/10.1016%2Fj.yjmcc.2017.11.009
TI - Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves
T2 - Journal of Molecular and Cellular Cardiology
AU - Kostina, A.A.
AU - Shishkova, A
AU - Игнатьева, Е.В.
AU - Irtyuga, O.
AU - Bogdanova, M.
AU - Levchuk, K.
AU - Golovkin, Alexey
AU - Zhiduleva, E
AU - Uspenskiy, Vladimir
AU - Moiseeva, O.
AU - Faggian, Giuseppe
AU - Vaage, Jarle
AU - Kostareva, Anna
AU - Rutkovskiy, A
AU - Malashicheva, Anna В.
PY - 2018
DA - 2018/01/01 00:00:00
PB - Elsevier
SP - 211-219
VL - 114
SN - 0022-2828
SN - 1095-8584
ER -
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@article{2018_Kostina,
author = {A.A. Kostina and A Shishkova and Е.В. Игнатьева and O. Irtyuga and M. Bogdanova and K. Levchuk and Alexey Golovkin and E Zhiduleva and Vladimir Uspenskiy and O. Moiseeva and Giuseppe Faggian and Jarle Vaage and Anna Kostareva and A Rutkovskiy and Anna В. Malashicheva},
title = {Different Notch signaling in cells from calcified bicuspid and tricuspid aortic valves},
journal = {Journal of Molecular and Cellular Cardiology},
year = {2018},
volume = {114},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.yjmcc.2017.11.009},
pages = {211--219},
doi = {10.1016/j.yjmcc.2017.11.009}
}
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