Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references
I.Victor Ekhato
1
,
Tim Hurley
1
,
Michael Lovdahl
1
,
T.J Revitte
1
,
Luyi Guo
1
,
Yun Huang
1
,
Scott Clipper
1
,
Charles Colson
1
1
Department of Chemical Research and Development, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
|
Publication type: Journal Article
Publication date: 2002-03-01
scimago Q2
wos Q3
SJR: 0.620
CiteScore: 4.3
Impact factor: 2.3
ISSN: 0039128X, 18785867
PubMed ID:
11856540
Organic Chemistry
Biochemistry
Molecular Biology
Pharmacology
Clinical Biochemistry
Endocrinology
Abstract
Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. All eight products result from oxidation of the A and/or B rings of the parent compounds. Oxidation of the heteroannular 3,5 dienyl acetate derivative of NA resulted in the 6 alpha-hydroxy, 6 beta-hydroxy and 6-keto NA. Oxidation of 6-keto NA led to the preparation of 6 alpha-hydroxy, 6 beta-hydroxy, 6-keto- and Delta(6) EE. Delta(11) EE was prepared from estrone.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Journal of Pharmaceutical and Biomedical Analysis
2 publications, 18.18%
|
|
|
Journal of Pharmaceutical Sciences
1 publication, 9.09%
|
|
|
Acta Crystallographica Section E Structure Reports Online
1 publication, 9.09%
|
|
|
Journal of Central South University of Technology
1 publication, 9.09%
|
|
|
Journal of Chemical Crystallography
1 publication, 9.09%
|
|
|
Chemosphere
1 publication, 9.09%
|
|
|
Steroids
1 publication, 9.09%
|
|
|
European Journal of Organic Chemistry
1 publication, 9.09%
|
|
|
Organic and Biomolecular Chemistry
1 publication, 9.09%
|
|
|
Journal of Analytical Chemistry
1 publication, 9.09%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
|
|
|
Elsevier
5 publications, 45.45%
|
|
|
Springer Nature
2 publications, 18.18%
|
|
|
International Union of Crystallography (IUCr)
1 publication, 9.09%
|
|
|
Wiley
1 publication, 9.09%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 9.09%
|
|
|
Pleiades Publishing
1 publication, 9.09%
|
|
|
1
2
3
4
5
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
11
Total citations:
11
Citations from 2024:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Ekhato I. et al. Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references // Steroids. 2002. Vol. 67. No. 3-4. pp. 165-174.
GOST all authors (up to 50)
Copy
Ekhato I., Hurley T., Lovdahl M., Revitte T., Guo L., Huang Y., Clipper S., Colson C. Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references // Steroids. 2002. Vol. 67. No. 3-4. pp. 165-174.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/s0039-128x(01)00149-0
UR - https://doi.org/10.1016/s0039-128x(01)00149-0
TI - Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references
T2 - Steroids
AU - Ekhato, I.Victor
AU - Hurley, Tim
AU - Lovdahl, Michael
AU - Revitte, T.J
AU - Guo, Luyi
AU - Huang, Yun
AU - Clipper, Scott
AU - Colson, Charles
PY - 2002
DA - 2002/03/01
PB - Elsevier
SP - 165-174
IS - 3-4
VL - 67
PMID - 11856540
SN - 0039-128X
SN - 1878-5867
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2002_Ekhato,
author = {I.Victor Ekhato and Tim Hurley and Michael Lovdahl and T.J Revitte and Luyi Guo and Yun Huang and Scott Clipper and Charles Colson},
title = {Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references},
journal = {Steroids},
year = {2002},
volume = {67},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/s0039-128x(01)00149-0},
number = {3-4},
pages = {165--174},
doi = {10.1016/s0039-128x(01)00149-0}
}
Cite this
MLA
Copy
Ekhato, I.Victor, et al. “Norethindrone acetate (NA) and ethinyl estradiol (EE) related oxidative transformation products in stability samples of formulated drug product: synthesis of authentic references.” Steroids, vol. 67, no. 3-4, Mar. 2002, pp. 165-174. https://doi.org/10.1016/s0039-128x(01)00149-0.