,
volume 726
,
issue 1-2
,
pages 141-148
Excretion study of the β2-agonist reproterol in human urine
1
Doping Control Laboratory of Athens, Olympic Athletic Center of Athens, Maroussi, Greece.
|
2
Doping Control Laboratory of Athens, Olympic Athletic Center of Athens, Kifissias 37, 15123 Maroussi, Greece
|
Publication type: Journal Article
Publication date: 1999-04-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 03784347, 13872273
PubMed ID:
10348180
General Chemistry
Abstract
An excretion study of the beta2-agonist 7-[3-[(beta-3,5-trihydroxyphenethyl)amino]-propyl]theophylline (reproterol) in human urine, which is reportedly misused by athletes and horses as a doping agent, is presented. The study was performed after an oral administration of 20 mg of reproterol hydrochloride. The collected urine samples were prepared using the standard anabolic steroid extraction procedure and analyzed by gas chromatography coupled with quadrupole mass spectrometry and, also, with high-resolution mass spectrometry (HRMS). The main reproterol metabolite was found, whereas unchanged reproterol was not detected. The structure of the main metabolite was confirmed by an accurate HRMS measurement of diagnostic ions. Finally, an excretion urine profile of the main metabolite is presented. The mass spectrum of another possible unidentified reproterol metabolite is also reported.
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Georgakopoulos C., Tsitsimpikou C., Spyridaki M. H. E. Excretion study of the β2-agonist reproterol in human urine // Journal of Chromatography B Biomedical Sciences and Applications. 1999. Vol. 726. No. 1-2. pp. 141-148.
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Georgakopoulos C., Tsitsimpikou C., Spyridaki M. H. E. Excretion study of the β2-agonist reproterol in human urine // Journal of Chromatography B Biomedical Sciences and Applications. 1999. Vol. 726. No. 1-2. pp. 141-148.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/s0378-4347(99)00033-x
UR - https://doi.org/10.1016/s0378-4347(99)00033-x
TI - Excretion study of the β2-agonist reproterol in human urine
T2 - Journal of Chromatography B Biomedical Sciences and Applications
AU - Georgakopoulos, C
AU - Tsitsimpikou, C
AU - Spyridaki, M H E
PY - 1999
DA - 1999/04/01
PB - Elsevier
SP - 141-148
IS - 1-2
VL - 726
PMID - 10348180
SN - 0378-4347
SN - 1387-2273
ER -
Cite this
BibTex (up to 50 authors)
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@article{1999_Georgakopoulos,
author = {C Georgakopoulos and C Tsitsimpikou and M H E Spyridaki},
title = {Excretion study of the β2-agonist reproterol in human urine},
journal = {Journal of Chromatography B Biomedical Sciences and Applications},
year = {1999},
volume = {726},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/s0378-4347(99)00033-x},
number = {1-2},
pages = {141--148},
doi = {10.1016/s0378-4347(99)00033-x}
}
Cite this
MLA
Copy
Georgakopoulos, C., et al. “Excretion study of the β2-agonist reproterol in human urine.” Journal of Chromatography B Biomedical Sciences and Applications, vol. 726, no. 1-2, Apr. 1999, pp. 141-148. https://doi.org/10.1016/s0378-4347(99)00033-x.