Journal of Chromatography A, volume 559, issue 1-2, pages 455-465
Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders
Publication type: Journal Article
Publication date: 1991-10-01
Journal:
Journal of Chromatography A
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.1
ISSN: 00219673, 18733778
Organic Chemistry
Biochemistry
General Medicine
Analytical Chemistry
Abstract
High-performance capillary electrophoresis (HPCE) has been used in a multicomponent analytical system designed to diagnose and study human diseases, particularly metabolic disorders. Comparative analyses, using HPCE, high-performance liquid chromatography (HPLC) and an automated amino acid analyser, were carried out on urine and blood samples from patients with homocystinuria, cystinuria, glutathione synthetase deficiency and adenylosuccinase deficiency. HPCE of the sulphur-containing amino compounds, derivatized with monobromobimane and detected by fluorescence spectroscopy, was a quick and simple alternative to classical amino acid analysis. The detection of the characteristic succinylpurines associated with adenylosuccinase defect was equally well achieved with HPLC and HPCE (absorbance detector). Owing to the possible connection between deficiency of taurine (2-amino-1-ethanesulphonic acid) in the heart and the development of cardiomyopathy and heart failure, a simple HPCE method was developed for the determination of taurine in sub-milligram samples of biopsies of the myocardium. The homologue 3-amino-1-propanesulphonic acid was the internal standard, and derivatives of 9-fluorenylmethyl chloroformate and fluorescence detection were used. It is suggested that the potential of HPCE to analyse small volumes should be exploited in biomedicine and clinical diagnosis to analyse sub-milligram samples of tissue biopsies and cells.
Top-30
Citations by journals
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Journal of Chromatography A
12 publications, 19.67%
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1 publication, 1.64%
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TrAC - Trends in Analytical Chemistry
1 publication, 1.64%
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1 publication, 1.64%
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1 publication, 1.64%
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1 publication, 1.64%
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Advances in Clinical Chemistry
1 publication, 1.64%
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1 publication, 1.64%
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Clinical Chemistry and Laboratory Medicine
1 publication, 1.64%
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1 publication, 1.64%
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1 publication, 1.64%
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Russian Chemical Reviews
1 publication, 1.64%
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Citations by publishers
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Elsevier
36 publications, 59.02%
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Wiley
8 publications, 13.11%
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Springer Nature
5 publications, 8.2%
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American Association for Clinical Chemistry
2 publications, 3.28%
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S. Karger AG
1 publication, 1.64%
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Royal Society of Chemistry (RSC)
1 publication, 1.64%
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Taylor & Francis
1 publication, 1.64%
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Walter de Gruyter
1 publication, 1.64%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 1.64%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Jellum E., Thorsrud A. K., Time E. Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders // Journal of Chromatography A. 1991. Vol. 559. No. 1-2. pp. 455-465.
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Jellum E., Thorsrud A. K., Time E. Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders // Journal of Chromatography A. 1991. Vol. 559. No. 1-2. pp. 455-465.
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TY - JOUR
DO - 10.1016/0021-9673(91)80093-v
UR - https://doi.org/10.1016/0021-9673(91)80093-v
TI - Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders
T2 - Journal of Chromatography A
AU - Jellum, Egil
AU - Thorsrud, Anne Karine
AU - Time, Ellen
PY - 1991
DA - 1991/10/01 00:00:00
PB - Elsevier
SP - 455-465
IS - 1-2
VL - 559
SN - 0021-9673
SN - 1873-3778
ER -
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@article{1991_Jellum,
author = {Egil Jellum and Anne Karine Thorsrud and Ellen Time},
title = {Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders},
journal = {Journal of Chromatography A},
year = {1991},
volume = {559},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/0021-9673(91)80093-v},
number = {1-2},
pages = {455--465},
doi = {10.1016/0021-9673(91)80093-v}
}
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Jellum, Egil, et al. “Capillary electrophoresis for diagnosis and studies of human disease, particularly metabolic disorders.” Journal of Chromatography A, vol. 559, no. 1-2, Oct. 1991, pp. 455-465. https://doi.org/10.1016/0021-9673(91)80093-v.