Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid
Тип публикации: Journal Article
Дата публикации: 1986-04-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 02621746
PubMed ID:
3012585
Biochemistry
Endocrinology
Physiology
Краткое описание
12S-Hydroperoxy-5,8,10,14,17-icosapentaenoic acid (12S-HPEPE), prepared by incubating rat platelet preparations with 14C-labelled icosapentaenoic acid and purified by HPLC, was transformed into hepoxilins A4 and B4 by treatment with bovine hemin in phosphate buffer. The identity of the products, purified by HPLC as methyl esters, was confirmed by GCMS analysis of the Me tBDMSi derivatives using both El and Cl detection and of the PFB TMSi derivatives using NlCl detection. In similarity to hepoxilin A3 and B3 derived from arachidonic acid, hepoxilin A4 and B4 also possess insulin secretagogue activity. This finding contrasts with observations in the prostaglandin series where products derived from icosapentaenoic acid have been reported to possess less potent biological actions.
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Pace-Asciak C. R. Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid // Prostaglandins Leukotrienes and Medicine. 1986. Vol. 22. No. 1. pp. 1-9.
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Pace-Asciak C. R. Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid // Prostaglandins Leukotrienes and Medicine. 1986. Vol. 22. No. 1. pp. 1-9.
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TY - JOUR
DO - 10.1016/0262-1746(86)90017-x
UR - https://doi.org/10.1016/0262-1746(86)90017-x
TI - Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid
T2 - Prostaglandins Leukotrienes and Medicine
AU - Pace-Asciak, C R
PY - 1986
DA - 1986/04/01
PB - Elsevier
SP - 1-9
IS - 1
VL - 22
PMID - 3012585
SN - 0262-1746
ER -
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@article{1986_Pace-Asciak,
author = {C R Pace-Asciak},
title = {Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid},
journal = {Prostaglandins Leukotrienes and Medicine},
year = {1986},
volume = {22},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/0262-1746(86)90017-x},
number = {1},
pages = {1--9},
doi = {10.1016/0262-1746(86)90017-x}
}
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MLA
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Pace-Asciak, C. R.. “Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid.” Prostaglandins Leukotrienes and Medicine, vol. 22, no. 1, Apr. 1986, pp. 1-9. https://doi.org/10.1016/0262-1746(86)90017-x.