Colloids and Surfaces B: Biointerfaces, volume 193, pages 111062
Intracellular delivery of drugs by chitosan-based multi-liposomal complexes
Grozdova Irina D
1
,
Efimova Anna A.
1
,
Ежов А. А.
2
,
Krivtsov George
3
,
Litmanovich Ekaterina
1
,
Yaroslavov A.A.
1
Publication type: Journal Article
Publication date: 2020-09-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.8
ISSN: 09277765, 18734367
PubMed ID:
32388392
Physical and Theoretical Chemistry
General Medicine
Colloid and Surface Chemistry
Biotechnology
Surfaces and Interfaces
Abstract
Positively charged linear chitosan molecules were cross-linked with sulfate-anions to form chitosan nanoparticles which were used as a scaffold of negatively charged cardiolipin/egg lecithin liposomes loaded with doxorubicin (DOX). Thus formed multi-liposomal complexes (MLCs) containing 55 liposomes/chitosan and bearing a slight positive net charge effectively transmitted DOX into the cytoplasm of cells in culture. The efficiency of DOX delivery increased 4-5-fold upon drug incorporation in MLCs. Inside the cells, the penetrated MLCs released DOX thus enabling its accumulation in the nuclei and interaction with its intracellular target DNA leading to a decrease in cell survival. The effects were demonstrated on 3T3 line of mouse fibroblasts, drug sensitive tumor MCF-7 cells and drug resistant human ovarian carcinoma OVCAR-8 cells (formerly called MCF-7/ADR). Thus, MLC particles can be used for effective delivery of payloads in cells of different origin.
Citations by journals
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1
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3
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Russian Journal of General Chemistry
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Russian Journal of General Chemistry
3 publications, 30%
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International Journal of Biological Macromolecules
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International Journal of Biological Macromolecules
1 publication, 10%
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Pharmaceutics
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Pharmaceutics
1 publication, 10%
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Mendeleev Communications
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Mendeleev Communications
1 publication, 10%
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Materials Today Advances
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Materials Today Advances
1 publication, 10%
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Biochimica et Biophysica Acta - Biomembranes
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Biochimica et Biophysica Acta - Biomembranes
1 publication, 10%
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Colloid Journal
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Colloid Journal
1 publication, 10%
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1
2
3
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Citations by publishers
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1
2
3
4
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Elsevier
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Elsevier
4 publications, 40%
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Pleiades Publishing
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Pleiades Publishing
4 publications, 40%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 10%
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1
2
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4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Grozdova I. D. et al. Intracellular delivery of drugs by chitosan-based multi-liposomal complexes // Colloids and Surfaces B: Biointerfaces. 2020. Vol. 193. p. 111062.
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Grozdova I. D., Melik-Nubarov N. S., Efimova A. A., Ежов А. А., Krivtsov G., Litmanovich E., Yaroslavov A. Intracellular delivery of drugs by chitosan-based multi-liposomal complexes // Colloids and Surfaces B: Biointerfaces. 2020. Vol. 193. p. 111062.
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TY - JOUR
DO - 10.1016/J.COLSURFB.2020.111062
UR - https://doi.org/10.1016%2FJ.COLSURFB.2020.111062
TI - Intracellular delivery of drugs by chitosan-based multi-liposomal complexes
T2 - Colloids and Surfaces B: Biointerfaces
AU - Grozdova, Irina D
AU - Melik-Nubarov, Nikolay S.
AU - Efimova, Anna A.
AU - Ежов, А. А.
AU - Krivtsov, George
AU - Litmanovich, Ekaterina
AU - Yaroslavov, A.A.
PY - 2020
DA - 2020/09/01 00:00:00
PB - Elsevier
SP - 111062
VL - 193
PMID - 32388392
SN - 0927-7765
SN - 1873-4367
ER -
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@article{2020_Grozdova,
author = {Irina D Grozdova and Nikolay S. Melik-Nubarov and Anna A. Efimova and А. А. Ежов and George Krivtsov and Ekaterina Litmanovich and A.A. Yaroslavov},
title = {Intracellular delivery of drugs by chitosan-based multi-liposomal complexes},
journal = {Colloids and Surfaces B: Biointerfaces},
year = {2020},
volume = {193},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2FJ.COLSURFB.2020.111062},
pages = {111062},
doi = {10.1016/J.COLSURFB.2020.111062}
}