Laboratory of Functional Polymers and Polymeric Materials
The work of our laboratory is aimed at studying the patterns of interaction of polymers with cells and the creation of new polymer systems capable of selectively suppressing the growth of cancer cells.
In the last 6-7 years, the main attention has been paid to polymer systems capable of generating singlet carbon as a result of reaction with biogenic hydrogen peroxide produced by cancer cells. Polymer systems capable of emitting light and generating singlet oxygen in contact with cancer cells producing increased amounts of hydrogen peroxide have been developed.
These polymer systems consist of three main components: aromatic esters of oxalic acid (oxalates), a photosensitizer, which can be porphyrin and a number of other organic and organometallic compounds, and an amphiphilic copolymer, which allows to obtain a stable colloidal system of water-insoluble components and protect these components from the destructive action of water.
The most important condition for the applicability of such systems in antitumor therapy is their biocompatibility. Therefore, our laboratory is conducting research on the synthesis of biodegradable amphiphilic copolymers with high affinity for components of the chemiluminescent system.
- Fluorescence Spectroscopy
- Column chromatography
- Thin-layer chromatography
- High-efficiency liquid chromatography (HPLC)
- Cell and tissue culture
- Fluorescence microscopy
- High-resolution transmission microscopy
- Polymerization with cycle opening
- Chemiluminescence
- Chemically induced photodynamic therapy
- Dynamic light scattering (DLS)