International Journal of Biological Macromolecules, volume 177, pages 455-462
Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity
Publication type: Journal Article
Publication date: 2021-04-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 8.2
ISSN: 01418130, 18790003
PubMed ID:
33636261
Biochemistry
Molecular Biology
General Medicine
Structural Biology
Abstract
Anionic liposomes were electrostatically adsorbed onto the surface of cationic chitosan particles cross-linked by sulfate anions, forming multi-liposomal containers (MLCs) for encapsulation and delivery of bioactive substances. An increase in molecular mass of chitosan from 30 to 300 kDa results in a size increase of chitosan particles, from 200 to 400 nm. Being saturated by liposomes, chitosan particles give MLCs of 320–540 nm. Each chitosan particle carries between 60 and 200 liposomes. The proteolytic complex Morikrase, a mixture of enzymes with various specificities, induces degradation of MLCs down to particles of size 10–15 nm; the higher the molecular mass of chitosan, the slower the enzyme-induced MLCs' degradation. pH variation within 5.5–7 and cholesterol incorporation into the liposomal membrane both have a minor effect on the rate of MLCs' biodegradation. Both the MLCs and the products of their biodegradation show low cytotoxicity. These results are of interest for constructing biodegradable capacious carriers of bioactive substances. • Liposomes were adsorbed on chitosan particles forming multi-liposomal complexes (MLCs). • MLCs degraded, being attacked by proteolytic enzymes, down to 10–15 nm particles. • The longer chitosan macromolecules, the slower enzyme-induced degradation of MLC. • Variation in pH and cholesterol incorporation had slight effect on biodegradation rate. • MLCs and products of their biodegradation demonstrated low cytotoxicity.
Citations by journals
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1 publication, 5.56%
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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1 publication, 5.56%
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1 publication, 5.56%
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Taylor & Francis
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1 publication, 5.56%
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1 publication, 5.56%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 5.56%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Yaroslavov A. et al. Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity // International Journal of Biological Macromolecules. 2021. Vol. 177. pp. 455-462.
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Yaroslavov A., Efimova A. A., Krasnikov E. A., Trosheva K. S., Popov A. S., Melik-Nubarov N., Krivtsov G. G. Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity // International Journal of Biological Macromolecules. 2021. Vol. 177. pp. 455-462.
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TY - JOUR
DO - 10.1016/J.IJBIOMAC.2021.02.169
UR - https://doi.org/10.1016%2FJ.IJBIOMAC.2021.02.169
TI - Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity
T2 - International Journal of Biological Macromolecules
AU - Yaroslavov, A.A.
AU - Efimova, Anna A.
AU - Krasnikov, E A
AU - Trosheva, K S
AU - Popov, A. S.
AU - Melik-Nubarov, N.S.
AU - Krivtsov, G G
PY - 2021
DA - 2021/04/01 00:00:00
PB - Elsevier
SP - 455-462
VL - 177
PMID - 33636261
SN - 0141-8130
SN - 1879-0003
ER -
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@article{2021_Yaroslavov,
author = {A.A. Yaroslavov and Anna A. Efimova and E A Krasnikov and K S Trosheva and A. S. Popov and N.S. Melik-Nubarov and G G Krivtsov},
title = {Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity},
journal = {International Journal of Biological Macromolecules},
year = {2021},
volume = {177},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2FJ.IJBIOMAC.2021.02.169},
pages = {455--462},
doi = {10.1016/J.IJBIOMAC.2021.02.169}
}
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