Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
Publication type: Journal Article
Publication date: 2018-05-26
scimago Q3
wos Q3
SJR: 0.305
CiteScore: 3.0
Impact factor: 1.7
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Racemic Albicar (2,6-diethyl-4,8-dimethylglycoluril) has been synthesized and resolved into enantiomers on a preparative scale by chiral HPLC. A comparison of the pharmacological effects of these compounds has been performed for the first time. It has been demonstrated that the (−)-(1S,5S)-enantiomer exerts a stimulating effect on the central nervous system due to activation of the serotonergic system, since it potentiates the effects of 5-hydroxytryptophan (the serotonin precursor), while the antagonist of serotonin receptors blocks its activity; the (+)-(1R,5R)-enantiomer evinces an inhibitory effect.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Mendeleev Communications
4 publications, 17.39%
|
|
|
Journal of Molecular Liquids
4 publications, 17.39%
|
|
|
Russian Journal of Organic Chemistry
2 publications, 8.7%
|
|
|
Synthesis
1 publication, 4.35%
|
|
|
Russian Chemical Bulletin
1 publication, 4.35%
|
|
|
Tetrahedron Letters
1 publication, 4.35%
|
|
|
CrystEngComm
1 publication, 4.35%
|
|
|
New Journal of Chemistry
1 publication, 4.35%
|
|
|
Chemistry of Heterocyclic Compounds
1 publication, 4.35%
|
|
|
Molecular Diversity
1 publication, 4.35%
|
|
|
Journal of Molecular Modeling
1 publication, 4.35%
|
|
|
Russian Chemical Reviews
1 publication, 4.35%
|
|
|
Journal of Fluorine Chemistry
1 publication, 4.35%
|
|
|
Russian Journal of General Chemistry
1 publication, 4.35%
|
|
|
Журнал органической химии
1 publication, 4.35%
|
|
|
Журнал Общей Химии
1 publication, 4.35%
|
|
|
1
2
3
4
|
Publishers
|
1
2
3
4
5
6
|
|
|
Elsevier
6 publications, 26.09%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
4 publications, 17.39%
|
|
|
Springer Nature
4 publications, 17.39%
|
|
|
Pleiades Publishing
4 publications, 17.39%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 8.7%
|
|
|
Georg Thieme Verlag KG
1 publication, 4.35%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 4.35%
|
|
|
Akademizdatcenter Nauka
1 publication, 4.35%
|
|
|
1
2
3
4
5
6
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
23
Total citations:
23
Citations from 2024:
3
(13%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Anikina L. V. et al. Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 317-319.
GOST all authors (up to 50)
Copy
Anikina L. V., Kravchenko A. N., Vikharev Y. B., Baranov V. V., Malyshev O. B. Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 317-319.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/J.MENCOM.2018.05.030
UR - https://linkinghub.elsevier.com/retrieve/pii/S0959943618301287
TI - Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
T2 - Mendeleev Communications
AU - Anikina, Lada V
AU - Kravchenko, Angelina N.
AU - Vikharev, Yuri B
AU - Baranov, Vladimir V.
AU - Malyshev, O. B.
PY - 2018
DA - 2018/05/26
PB - OOO Zhurnal "Mendeleevskie Soobshcheniya"
SP - 317-319
IS - 3
VL - 28
SN - 0959-9436
SN - 1364-551X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Anikina,
author = {Lada V Anikina and Angelina N. Kravchenko and Yuri B Vikharev and Vladimir V. Baranov and O. B. Malyshev},
title = {Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {OOO Zhurnal "Mendeleevskie Soobshcheniya"},
month = {may},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0959943618301287},
number = {3},
pages = {317--319},
doi = {10.1016/J.MENCOM.2018.05.030}
}
Cite this
MLA
Copy
Anikina, Lada V., et al. “Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers.” Mendeleev Communications, vol. 28, no. 3, May. 2018, pp. 317-319. https://linkinghub.elsevier.com/retrieve/pii/S0959943618301287.
Profiles