Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives
I.V. Ovchinnikov
1
,
A.S Kulikov
1
,
P Tosco
2
,
A Di Stilo
2
,
A. Gasco
2
,
Nina N. Makhova
1
,
Roberta Fruttero
2
2
Dipartimento di Scienza e Tecnologia del Farmaco, Facoltà di Farmacia, Via P. Giuria 9, I-10125 Torino, Italy
|
Publication type: Journal Article
Publication date: 2003-09-01
PubMed ID:
13679160
Drug Discovery
Pharmaceutical Science
Abstract
A series of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acids 5a-11a and their oxidation products, the azo derivatives 5b-11b, were synthesised and studied for their vasodilating properties. All the products were able to release rat aorta strips precontracted with (-)noradrenaline. Azo derivatives proved to be 20-200 times more potent than the parent amines. The large variation of lipophilicity within the two series does not seem to influence significantly the activity. Experiments carried out in the presence of oxyhaemoglobin (HbO(2)) suggest the involvement of nitric oxide (NO*) in the vasodilation.
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GOST
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Kulikov A. et al. Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives // Il Farmaco. 2003. Vol. 58. No. 9. pp. 677-681.
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Ovchinnikov I., Kulikov A., Tosco P., Di Stilo A., Gasco A., Makhova N. N., Fruttero R. Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives // Il Farmaco. 2003. Vol. 58. No. 9. pp. 677-681.
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RIS
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TY - JOUR
DO - 10.1016/S0014-827X(03)00106-X
UR - https://doi.org/10.1016/S0014-827X(03)00106-X
TI - Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives
T2 - Il Farmaco
AU - Ovchinnikov, I.V.
AU - Kulikov, A.S
AU - Tosco, P
AU - Di Stilo, A
AU - Gasco, A.
AU - Makhova, Nina N.
AU - Fruttero, Roberta
PY - 2003
DA - 2003/09/01
PB - Elsevier
SP - 677-681
IS - 9
VL - 58
PMID - 13679160
SN - 0014-827X
ER -
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BibTex (up to 50 authors)
Copy
@article{2003_Kulikov,
author = {I.V. Ovchinnikov and A.S Kulikov and P Tosco and A Di Stilo and A. Gasco and Nina N. Makhova and Roberta Fruttero},
title = {Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives},
journal = {Il Farmaco},
year = {2003},
volume = {58},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/S0014-827X(03)00106-X},
number = {9},
pages = {677--681},
doi = {10.1016/S0014-827X(03)00106-X}
}
Cite this
MLA
Copy
Kulikov, A.S, et al. “Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives.” Il Farmaco, vol. 58, no. 9, Sep. 2003, pp. 677-681. https://doi.org/10.1016/S0014-827X(03)00106-X.
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