Heterocyclic NO prodrugs
1
HMR Research Chemistry, Frankfurt, Germany.
|
Publication type: Journal Article
Publication date: 1999-05-01
PubMed ID:
10418124
Drug Discovery
Pharmaceutical Science
Abstract
An overview of the different heterocyclic NO-releasing compounds is given. Mesoionic heterocycles like sydnone imines are one example. This class is discussed on the synthesis and the mechanism of NO formation from Molsidomine and its first metabolite SIN-1. Furthermore, 1,2,3,4 oxatriazolium olates and imidates are presented in an example of the synthesis of GEA-3175. Heterocyclic N-oxides are another group of compounds capable of NO release under certain conditions. This class is discussed in the example of furoxane carboxamides like CAS-1609, and some SAR-data show the great impact of intramolecular hydrogen bridges on their in vitro activity. Each class of compounds requires different cofactors for NO release: sydnone imines need oxidants like oxygen, furoxanes are converted to NO via reaction with thioles.
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Metrics
71
Total citations:
71
Citations from 2025:
2
(2.82%)
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GOST |
RIS |
BibTex |
MLA
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/S0014-827X(99)00031-2
UR - https://doi.org/10.1016/S0014-827X(99)00031-2
TI - Heterocyclic NO prodrugs
T2 - Il Farmaco
AU - Schönafinger, Karl
PY - 1999
DA - 1999/05/01
PB - Elsevier
SP - 316-320
IS - 5
VL - 54
PMID - 10418124
SN - 0014-827X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1999_Schönafinger,
author = {Karl Schönafinger},
title = {Heterocyclic NO prodrugs},
journal = {Il Farmaco},
year = {1999},
volume = {54},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/S0014-827X(99)00031-2},
number = {5},
pages = {316--320},
doi = {10.1016/S0014-827X(99)00031-2}
}
Cite this
MLA
Copy
Schönafinger, Karl. “Heterocyclic NO prodrugs.” Il Farmaco, vol. 54, no. 5, May. 1999, pp. 316-320. https://doi.org/10.1016/S0014-827X(99)00031-2.