Journal of Molecular Biology, volume 215, issue 3, pages 403-410

Basic local alignment search tool

Stephen F. Altschul ¹

WARREN GISH ¹

WEBB MILLER ²

Eugene W. Myers ³

David J. Lipman ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

National Center for Biotechnology Information National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, U.S.A.

United States National Library of Medicine

National Center for Biotechnology Information

Department of Computer Science The Pennsylvania State University, University Park, PA 16802, U.S.A. |

Department of Computer Science, University of Arizona, Tucson, AZ 85721, U.S.A. |

Publication type: Journal Article

Publication date: 1990-10-01

Elsevier

Journal: Journal of Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor: 5.6

ISSN: 00222836, 10898638

DOI: 10.1016/S0022-2836(05)80360-2

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Molecular Biology

Structural Biology

Abstract

A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score. Recent mathematical results on the stochastic properties of MSP scores allow an analysis of the performance of this method as well as the statistical significance of alignments it generates. The basic algorithm is simple and robust; it can be implemented in a number of ways and applied in a variety of contexts including straightforward DNA and protein sequence database searches, motif searches, gene identification searches, and in the analysis of multiple regions of similarity in long DNA sequences. In addition to its flexibility and tractability to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity.

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GOST |

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GOST Copy

Altschul S. F. et al. Basic local alignment search tool // Journal of Molecular Biology. 1990. Vol. 215. No. 3. pp. 403-410.

GOST all authors (up to 50) Copy

Altschul S. F., GISH W., MILLER W., Myers E. W., Lipman D. J. Basic local alignment search tool // Journal of Molecular Biology. 1990. Vol. 215. No. 3. pp. 403-410.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/S0022-2836(05)80360-2

UR - https://doi.org/10.1016/S0022-2836(05)80360-2

TI - Basic local alignment search tool

T2 - Journal of Molecular Biology

AU - Altschul, Stephen F.

AU - GISH, WARREN

AU - MILLER, WEBB

AU - Myers, Eugene W.

AU - Lipman, David J.

PY - 1990

DA - 1990/10/01

PB - Elsevier

SP - 403-410

IS - 3

VL - 215

SN - 0022-2836

SN - 1089-8638

ER -

BibTex |

Cite this

BibTex Copy

@article{1990_Altschul,

author = {Stephen F. Altschul and WARREN GISH and WEBB MILLER and Eugene W. Myers and David J. Lipman},

title = {Basic local alignment search tool},

journal = {Journal of Molecular Biology},

year = {1990},

volume = {215},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/S0022-2836(05)80360-2},

number = {3},

pages = {403--410},

doi = {10.1016/S0022-2836(05)80360-2}

}

MLA

Cite this

MLA Copy

Altschul, Stephen F., et al. “Basic local alignment search tool.” Journal of Molecular Biology, vol. 215, no. 3, Oct. 1990, pp. 403-410. https://doi.org/10.1016/S0022-2836(05)80360-2.

Found error?

Publisher

Elsevier

Journal

Journal of Molecular Biology

Quartile SCImago

Quartile WOS

Impact factor

5.6

ISSN

00222836 ()
10898638 ()