Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base
Тип публикации: Journal Article
Дата публикации: 2002-04-01
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.152
CiteScore: 10.8
Impact factor: 6.7
ISSN: 02235234, 17683254
PubMed ID:
11960666
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Краткое описание
We report the synthesis of an asymmetric Tröger base containing the two well characterised DNA binding chromophores, proflavine and phenanthroline. The mode of interaction of the hybrid molecule was investigated by circular and linear dichroism experiments and a biochemical assay using DNA topoisomerase I. The data are compatible with a model in which the proflavine moiety intercalates between DNA base pairs and the phenanthroline ring occupies the DNA groove. DNase I cleavage experiments were carried out to investigate the sequence preference of the hybrid ligand and a well resolved footprint was detected at a site encompassing two adjacent 5'-GTC.5-GAC triplets. The sequence preference of the asymmetric molecule is compared to that of the symmetric analogues.
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ГОСТ
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Baldeyrou B. et al. Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base // European Journal of Medicinal Chemistry. 2002. Vol. 37. No. 4. pp. 315-322.
ГОСТ со всеми авторами (до 50)
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Baldeyrou B., Tardy C., Bailly C., Colson P., Houssier C., Charmantray F., Demeunynck M. Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base // European Journal of Medicinal Chemistry. 2002. Vol. 37. No. 4. pp. 315-322.
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TY - JOUR
DO - 10.1016/S0223-5234(02)01356-9
UR - https://doi.org/10.1016/S0223-5234(02)01356-9
TI - Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base
T2 - European Journal of Medicinal Chemistry
AU - Baldeyrou, Brigitte
AU - Tardy, Christelle
AU - Bailly, Christian
AU - Colson, Pierre
AU - Houssier, Claude
AU - Charmantray, Franck
AU - Demeunynck, Martine
PY - 2002
DA - 2002/04/01
PB - Elsevier
SP - 315-322
IS - 4
VL - 37
PMID - 11960666
SN - 0223-5234
SN - 1768-3254
ER -
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@article{2002_Baldeyrou,
author = {Brigitte Baldeyrou and Christelle Tardy and Christian Bailly and Pierre Colson and Claude Houssier and Franck Charmantray and Martine Demeunynck},
title = {Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base},
journal = {European Journal of Medicinal Chemistry},
year = {2002},
volume = {37},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/S0223-5234(02)01356-9},
number = {4},
pages = {315--322},
doi = {10.1016/S0223-5234(02)01356-9}
}
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MLA
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Baldeyrou, Brigitte, et al. “Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base.” European Journal of Medicinal Chemistry, vol. 37, no. 4, Apr. 2002, pp. 315-322. https://doi.org/10.1016/S0223-5234(02)01356-9.
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