Photosensitizers related to purpurin-18-N-alkylimides: a comparative in vivo tumoricidal ability of ester versus amide functionalities.
Тип публикации: Journal Article
Дата публикации: 2000-01-01
SCImago Q2
WOS Q2
БС2
SJR: 0.426
CiteScore: 4.5
Impact factor: 2.3
ISSN: 0960894X, 14643405
PubMed ID:
10673094
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
For a comparative study, 3-(alkyloxyethyl)-3-devinylpurpurin-18-N-hexylimides with ester and amide functionalities were investigated for tumor selectivity and in vivo photosensitizing efficacy. Compared to amide analogues, the related photosensitizers with ester functionalities were found to be more effective. Among these compounds the 3-devinyl-(3-hexyloxyethyl)-purpurin-18-N-hexylimide as methyl ester 12 showed excellent tumor uptake (tumor versus muscle ratio: 8:1), and produced 100% tumor cure on day 30 at a dose of 1.0 micromol/kg. The mice were treated with light (135 J/cm2, 705 nm) at 24 h post injection of the drug.
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Zheng Gang G. et al. Photosensitizers related to purpurin-18-N-alkylimides: a comparative in vivo tumoricidal ability of ester versus amide functionalities. // Bioorganic and Medicinal Chemistry Letters. 2000. Vol. 10. No. 2. pp. 123-127.
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Zheng G., Potter W. J., Sumlin A., Dougherty T. J., Pandey R. K. Photosensitizers related to purpurin-18-N-alkylimides: a comparative in vivo tumoricidal ability of ester versus amide functionalities. // Bioorganic and Medicinal Chemistry Letters. 2000. Vol. 10. No. 2. pp. 123-127.
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TY - JOUR
DO - 10.1016/S0960-894X(99)00649-6
UR - https://doi.org/10.1016/S0960-894X(99)00649-6
TI - Photosensitizers related to purpurin-18-N-alkylimides: a comparative in vivo tumoricidal ability of ester versus amide functionalities.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Zheng, Gang
AU - Potter, William J.
AU - Sumlin, Adam
AU - Dougherty, Thomas J.
AU - Pandey, Ravindra K.
PY - 2000
DA - 2000/01/01
PB - Elsevier
SP - 123-127
IS - 2
VL - 10
PMID - 10673094
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{2000_Zheng Gang,
author = {Gang Zheng and William J. Potter and Adam Sumlin and Thomas J. Dougherty and Ravindra K. Pandey},
title = {Photosensitizers related to purpurin-18-N-alkylimides: a comparative in vivo tumoricidal ability of ester versus amide functionalities.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2000},
volume = {10},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/S0960-894X(99)00649-6},
number = {2},
pages = {123--127},
doi = {10.1016/S0960-894X(99)00649-6}
}
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MLA
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Zheng Gang, Gang, et al. “Photosensitizers related to purpurin-18-N-alkylimides: a comparative in vivo tumoricidal ability of ester versus amide functionalities..” Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 2, Jan. 2000, pp. 123-127. https://doi.org/10.1016/S0960-894X(99)00649-6.
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