The methyl-branched fortifications of Mycobacterium tuberculosis.
Тип публикации: Journal Article
Дата публикации: 2002-05-01
PubMed ID:
12031661
Drug Discovery
Biochemistry
Molecular Biology
General Medicine
Pharmacology
Clinical Biochemistry
Molecular Medicine
Краткое описание
Mycobacterium tuberculosis continues to be the predominant global infectious agent, annually killing over three million people. Recommended drug regimens have the potential to control tuberculosis, but lack of adherence to such regimens has resulted in the emergence of resistant strains. Mycobacterium tuberculosis has an unusual cell envelope, rich in unique long-chain lipids, that provides a very hydrophobic barrier to antibiotic access. Such lipids, however, can be drug targets, as exemplified by the action of the front-line drug isoniazid on mycolic acid biosynthesis. A number of these lipids are potential key virulence factors and their structures are based on very characteristic methyl-branched long-chain acids and alcohols. This review details the history, structure, and genetic aspects of the biosynthesis of these methyl-branched components, good examples of which are the phthiocerols and the mycocerosic and mycolipenic acids.
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ГОСТ |
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BibTex |
MLA
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ГОСТ
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Minnikin D. E. et al. The methyl-branched fortifications of Mycobacterium tuberculosis. // Chemistry & Biology. 2002. Vol. 9. No. 5. pp. 545-553.
ГОСТ со всеми авторами (до 50)
Скопировать
Minnikin D. E., Kremer L., DOVER L. G., Besra G. S. The methyl-branched fortifications of Mycobacterium tuberculosis. // Chemistry & Biology. 2002. Vol. 9. No. 5. pp. 545-553.
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RIS
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TY - JOUR
DO - 10.1016/S1074-5521(02)00142-4
UR - https://doi.org/10.1016/S1074-5521(02)00142-4
TI - The methyl-branched fortifications of Mycobacterium tuberculosis.
T2 - Chemistry & Biology
AU - Minnikin, D E
AU - Kremer, Laurent
AU - DOVER, Lynn G.
AU - Besra, G. S.
PY - 2002
DA - 2002/05/01
PB - Elsevier
SP - 545-553
IS - 5
VL - 9
PMID - 12031661
SN - 1074-5521
SN - 1879-1301
ER -
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BibTex (до 50 авторов)
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@article{2002_Minnikin,
author = {D E Minnikin and Laurent Kremer and Lynn G. DOVER and G. S. Besra},
title = {The methyl-branched fortifications of Mycobacterium tuberculosis.},
journal = {Chemistry & Biology},
year = {2002},
volume = {9},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/S1074-5521(02)00142-4},
number = {5},
pages = {545--553},
doi = {10.1016/S1074-5521(02)00142-4}
}
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MLA
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Minnikin, D. E., et al. “The methyl-branched fortifications of Mycobacterium tuberculosis..” Chemistry & Biology, vol. 9, no. 5, May. 2002, pp. 545-553. https://doi.org/10.1016/S1074-5521(02)00142-4.
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