Bioorganic and Medicinal Chemistry

, volume 16 , issue 5 , pages 2550-2557

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

Na Xue ¹

Xiao-Chun Yang ^{2, 3, 4, 5, 6}

Rui Wu ^{2, 3, 4, 5, 6}

Jing Chen ¹

Qiaojun He ^{2, 3, 4, 5, 6}

Bo Yang ^{2, 3, 4, 5, 6}

Xiuyang Lu ⁷

Yongzhou Hu ¹

Hide authors affiliations Show authors affiliations: 7 affiliations

ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China |

Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences

ZheJiang University |

⁴

Hangzhou |

⁵

310058

⁶

CHINA |

⁷

Department of Chemical and Biochemical Engineering, College of Material Sciences and Chemical Engineering, Zhejiang University, Hangzhou 310027, China |

Publication type: Journal Article

Publication date: 2008-03-01

Elsevier

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

SJR: 0.608

CiteScore: 6.7

Impact factor: 3.0

ISSN: 09680896, 14643391

DOI: 10.1016/j.bmc.2007.11.048

Copy DOI

PubMed ID: 18226907

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.

Found

1 citation

Nelyubina Yulia

🤝

DSc in Chemistry

507 publications, 7 656 citations, 1 review

h-index: 38

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

Moscow Institute of Physics and Technology

Metal-organic frameworks

Quantum technologies

Sensors

1 citation

Gazizov Almir

🥼

DSc in Chemistry

159 publications, 911 citations, 23 reviews

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Heterocyclic compounds

Organic Chemistry

Organophosphorus chemistry

1 citation

Chugunova Elena

🤝

DSc in Chemistry

62 publications, 537 citations, 1 review

h-index: 13

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Kazan National Research Technological University

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GOST |

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GOST Copy

Xue N. et al. Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents // Bioorganic and Medicinal Chemistry. 2008. Vol. 16. No. 5. pp. 2550-2557.

GOST all authors (up to 50) Copy

Xue N., Yang X., Wu R., Chen J., He Q., Yang B., Lu X., Hu Y. Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents // Bioorganic and Medicinal Chemistry. 2008. Vol. 16. No. 5. pp. 2550-2557.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.bmc.2007.11.048

UR - https://doi.org/10.1016/j.bmc.2007.11.048

TI - Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents

T2 - Bioorganic and Medicinal Chemistry

AU - Xue, Na

AU - Yang, Xiao-Chun

AU - Wu, Rui

AU - Chen, Jing

AU - He, Qiaojun

AU - Yang, Bo

AU - Lu, Xiuyang

AU - Hu, Yongzhou

PY - 2008

DA - 2008/03/01

PB - Elsevier

SP - 2550-2557

IS - 5

VL - 16

PMID - 18226907

SN - 0968-0896

SN - 1464-3391

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2008_Xue,

author = {Na Xue and Xiao-Chun Yang and Rui Wu and Jing Chen and Qiaojun He and Bo Yang and Xiuyang Lu and Yongzhou Hu},

title = {Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents},

journal = {Bioorganic and Medicinal Chemistry},

year = {2008},

volume = {16},

publisher = {Elsevier},

month = {mar},

url = {https://doi.org/10.1016/j.bmc.2007.11.048},

number = {5},

pages = {2550--2557},

doi = {10.1016/j.bmc.2007.11.048}

}

MLA

Cite this

MLA Copy

Xue, Na, et al. “Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents.” Bioorganic and Medicinal Chemistry, vol. 16, no. 5, Mar. 2008, pp. 2550-2557. https://doi.org/10.1016/j.bmc.2007.11.048.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry

scimago Q2

wos Q1

SJR

0.608

CiteScore

6.7

Impact factor

3.0

ISSN

09680896 (Print)

14643391 (Electronic)