Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities
Publication type: Journal Article
Publication date: 2022-02-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
35063896
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties. Biological evaluation indicated that compound 23d exhibited excellently inhibitory activity on LPS-induced NO production in RAW264.7 cells (IC50 = 0.38 ± 0.18 μM). The preliminary structure-activity relationships (SARs) suggested that phenylsulfonyl substituted furoxan moiety had the strongest ability to improve anti-inflammatory activity of lathyrane diterpenoids. Furthermore, compound 23d significantly reduced the level of ROS. Its molecular mechanism was related to inhibiting the transcriptional activation of Nrf2/HO-1 pathway. Based on these considerations, 23d might be a promising anti-inflammatory agent, which is noteworthy for further exploration.
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Total citations:
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Citations from 2024:
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(50%)
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Wang W. et al. Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities // Bioorganic and Medicinal Chemistry. 2022. Vol. 56. p. 116627.
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Wang W., Xiong L., Li Y., Song Z., Sun D., Li H., Chen L. Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities // Bioorganic and Medicinal Chemistry. 2022. Vol. 56. p. 116627.
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TY - JOUR
DO - 10.1016/j.bmc.2022.116627
UR - https://doi.org/10.1016/j.bmc.2022.116627
TI - Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities
T2 - Bioorganic and Medicinal Chemistry
AU - Wang, W
AU - Xiong, L
AU - Li, Y
AU - Song, Z
AU - Sun, D
AU - Li, H
AU - Chen, L
PY - 2022
DA - 2022/02/01
PB - Elsevier
SP - 116627
VL - 56
PMID - 35063896
SN - 0968-0896
SN - 1464-3391
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Wang,
author = {W Wang and L Xiong and Y Li and Z Song and D Sun and H Li and L Chen},
title = {Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities},
journal = {Bioorganic and Medicinal Chemistry},
year = {2022},
volume = {56},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmc.2022.116627},
pages = {116627},
doi = {10.1016/j.bmc.2022.116627}
}