Structure–activity relationships of the oxindole growth hormone secretagogues
Teruhisa Tokunaga
1
,
W. Ewan Hume
1
,
Jun Nagamine
1
,
Tetsuya Kawamura
1
,
Mutsuo Taiji
1
,
Ryu Nagata
1
1
Research Division, Sumitomo Pharmaceuticals Co., Ltd, 1-98 Kasugade Naka 3-chome, Konohana-ku, Osaka 554-0022, Japan
|
Publication type: Journal Article
Publication date: 2005-04-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
15780607
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of substituted oxindole derivatives of SM-130686 was synthesized and evaluated as ghrelin receptor agonists. Modification of the substituents on the C3-aromatic part of the oxindole led to compounds with subnanomolar binding affinities. Compound 4i (IC(50)=0.02 nM) was orally active at low doses and showed in vivo activity when orally administered, 2 mg/kg twice a day for 4 days, as evidenced by significant body weight gain.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
2
4
6
8
10
12
|
|
|
Tetrahedron Letters
11 publications, 8.66%
|
|
|
Tetrahedron Asymmetry
6 publications, 4.72%
|
|
|
ChemistrySelect
6 publications, 4.72%
|
|
|
Journal of Organic Chemistry
6 publications, 4.72%
|
|
|
European Journal of Organic Chemistry
5 publications, 3.94%
|
|
|
Angewandte Chemie
5 publications, 3.94%
|
|
|
Organic Letters
5 publications, 3.94%
|
|
|
Organic and Biomolecular Chemistry
5 publications, 3.94%
|
|
|
Tetrahedron
4 publications, 3.15%
|
|
|
Asian Journal of Organic Chemistry
4 publications, 3.15%
|
|
|
Angewandte Chemie - International Edition
4 publications, 3.15%
|
|
|
Organic Chemistry Frontiers
4 publications, 3.15%
|
|
|
Chemical Communications
3 publications, 2.36%
|
|
|
Green Chemistry
3 publications, 2.36%
|
|
|
New Journal of Chemistry
3 publications, 2.36%
|
|
|
Synthesis
3 publications, 2.36%
|
|
|
Journal of the Electrochemical Society
2 publications, 1.57%
|
|
|
Bulletin of the Korean Chemical Society
2 publications, 1.57%
|
|
|
Chemistry - An Asian Journal
2 publications, 1.57%
|
|
|
Chemistry - A European Journal
2 publications, 1.57%
|
|
|
Advanced Synthesis and Catalysis
2 publications, 1.57%
|
|
|
Journal of Heterocyclic Chemistry
2 publications, 1.57%
|
|
|
Chemical Reviews
2 publications, 1.57%
|
|
|
Journal of Combinatorial Chemistry
2 publications, 1.57%
|
|
|
Journal of the American Chemical Society
2 publications, 1.57%
|
|
|
RSC Advances
2 publications, 1.57%
|
|
|
Synthetic Communications
2 publications, 1.57%
|
|
|
Molecular Pharmacology
1 publication, 0.79%
|
|
|
Chemistry Letters
1 publication, 0.79%
|
|
|
Canadian Journal of Chemistry
1 publication, 0.79%
|
|
|
2
4
6
8
10
12
|
Publishers
|
5
10
15
20
25
30
35
40
45
|
|
|
Wiley
43 publications, 33.86%
|
|
|
Elsevier
23 publications, 18.11%
|
|
|
Royal Society of Chemistry (RSC)
20 publications, 15.75%
|
|
|
American Chemical Society (ACS)
18 publications, 14.17%
|
|
|
Georg Thieme Verlag KG
5 publications, 3.94%
|
|
|
Taylor & Francis
4 publications, 3.15%
|
|
|
The Electrochemical Society
2 publications, 1.57%
|
|
|
Springer Nature
2 publications, 1.57%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 0.79%
|
|
|
Oxford University Press
1 publication, 0.79%
|
|
|
Canadian Science Publishing
1 publication, 0.79%
|
|
|
MDPI
1 publication, 0.79%
|
|
|
King Saud University
1 publication, 0.79%
|
|
|
Scientific Research Publishing
1 publication, 0.79%
|
|
|
Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society
1 publication, 0.79%
|
|
|
Trans Tech Publications
1 publication, 0.79%
|
|
|
S. Karger AG
1 publication, 0.79%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 0.79%
|
|
|
5
10
15
20
25
30
35
40
45
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
127
Total citations:
127
Citations from 2025:
1
(0.79%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Tokunaga T. et al. Structure–activity relationships of the oxindole growth hormone secretagogues // Bioorganic and Medicinal Chemistry Letters. 2005. Vol. 15. No. 7. pp. 1789-1792.
GOST all authors (up to 50)
Copy
Tokunaga T., Hume W. E., Nagamine J., Kawamura T., Taiji M., Nagata R. Structure–activity relationships of the oxindole growth hormone secretagogues // Bioorganic and Medicinal Chemistry Letters. 2005. Vol. 15. No. 7. pp. 1789-1792.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2005.02.042
UR - https://doi.org/10.1016/j.bmcl.2005.02.042
TI - Structure–activity relationships of the oxindole growth hormone secretagogues
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Tokunaga, Teruhisa
AU - Hume, W. Ewan
AU - Nagamine, Jun
AU - Kawamura, Tetsuya
AU - Taiji, Mutsuo
AU - Nagata, Ryu
PY - 2005
DA - 2005/04/01
PB - Elsevier
SP - 1789-1792
IS - 7
VL - 15
PMID - 15780607
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Tokunaga,
author = {Teruhisa Tokunaga and W. Ewan Hume and Jun Nagamine and Tetsuya Kawamura and Mutsuo Taiji and Ryu Nagata},
title = {Structure–activity relationships of the oxindole growth hormone secretagogues},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2005},
volume = {15},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.bmcl.2005.02.042},
number = {7},
pages = {1789--1792},
doi = {10.1016/j.bmcl.2005.02.042}
}
Cite this
MLA
Copy
Tokunaga, Teruhisa, et al. “Structure–activity relationships of the oxindole growth hormone secretagogues.” Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 7, Apr. 2005, pp. 1789-1792. https://doi.org/10.1016/j.bmcl.2005.02.042.