Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents
Larissa Kuznetsova
1
,
Jin Feng Chen
1
,
Liang Sun
1
,
Xinyuan Wu
1
,
Antonella Pepe
1
,
Jean M. Veith
2
,
Paula Pera
2
,
Ralph J. Bernacki
2
,
Iwao Ojima
1
1
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, USA.
|
2
Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Memorial Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
|
Publication type: Journal Article
Publication date: 2006-02-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
16298526
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Polyunsaturated fatty acids such as docosahexaenoic acid (DHA), linolenic acid, and linoleic acid were linked to the C-2' position of the second-generation taxoids that could overcome MDR caused by overexpressed ABC transporters. The new conjugates, tested in vivo, exhibited strong activity against drug-resistant colon cancer and drug-sensitive ovarian cancer xenografts in mice. Two of the new conjugates, DHA-SB-T-1214 and DHA-SB-T-1213, were found to achieve the total regression of drug-resistant and drug-sensitive tumors, respectively, in the animal models with substantially reduced systemic toxicity.
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Total citations:
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Citations from 2024:
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Kuznetsova L. et al. Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents // Bioorganic and Medicinal Chemistry Letters. 2006. Vol. 16. No. 4. pp. 974-977.
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Kuznetsova L., Chen J. F., Sun L., Wu X., Pepe A., Veith J. M., Pera P., Bernacki R. J., Ojima I. Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents // Bioorganic and Medicinal Chemistry Letters. 2006. Vol. 16. No. 4. pp. 974-977.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2005.10.089
UR - https://doi.org/10.1016/j.bmcl.2005.10.089
TI - Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Kuznetsova, Larissa
AU - Chen, Jin Feng
AU - Sun, Liang
AU - Wu, Xinyuan
AU - Pepe, Antonella
AU - Veith, Jean M.
AU - Pera, Paula
AU - Bernacki, Ralph J.
AU - Ojima, Iwao
PY - 2006
DA - 2006/02/01
PB - Elsevier
SP - 974-977
IS - 4
VL - 16
PMID - 16298526
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2006_Kuznetsova,
author = {Larissa Kuznetsova and Jin Feng Chen and Liang Sun and Xinyuan Wu and Antonella Pepe and Jean M. Veith and Paula Pera and Ralph J. Bernacki and Iwao Ojima},
title = {Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2006},
volume = {16},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmcl.2005.10.089},
number = {4},
pages = {974--977},
doi = {10.1016/j.bmcl.2005.10.089}
}
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MLA
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Kuznetsova, Larissa, et al. “Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.” Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 4, Feb. 2006, pp. 974-977. https://doi.org/10.1016/j.bmcl.2005.10.089.