Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation
Fabrizio Micheli
1
,
Alessandra Pasquarello
1
,
Giovanna Tedesco
1
,
Dieter Hamprecht
1
,
Giorgio Bonanomi
1
,
Anna Checchia
1
,
Albert Jaxa-Chamiec
2
,
Federica Damiani
1
,
Silvia Davalli
1
,
Daniele Donati
1
,
Chiara Gallotti
1
,
Marcella Petrone
1
,
Marilisa Rinaldi
1
,
GRAHAM J. RILEY
2
,
Silvia Terreni
1
,
Martyn Wood
2
1
GlaxoSmithKline, Psychiatry Centre of Excellence for Drug Discovery, Via Fleming 4, 37135 Verona, Italy.
|
2
NFSP, Harlow, Essex, UK
|
Тип публикации: Journal Article
Дата публикации: 2006-08-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
16730983
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C molecules are reported.
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ГОСТ
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Micheli F. et al. Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation // Bioorganic and Medicinal Chemistry Letters. 2006. Vol. 16. No. 15. pp. 3906-3912.
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Micheli F., Pasquarello A., Tedesco G., Hamprecht D., Bonanomi G., Checchia A., Jaxa-Chamiec A., Damiani F., Davalli S., Donati D., Gallotti C., Petrone M., Rinaldi M., RILEY G. J., Terreni S., Wood M. Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation // Bioorganic and Medicinal Chemistry Letters. 2006. Vol. 16. No. 15. pp. 3906-3912.
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TY - JOUR
DO - 10.1016/j.bmcl.2006.05.034
UR - https://doi.org/10.1016/j.bmcl.2006.05.034
TI - Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Micheli, Fabrizio
AU - Pasquarello, Alessandra
AU - Tedesco, Giovanna
AU - Hamprecht, Dieter
AU - Bonanomi, Giorgio
AU - Checchia, Anna
AU - Jaxa-Chamiec, Albert
AU - Damiani, Federica
AU - Davalli, Silvia
AU - Donati, Daniele
AU - Gallotti, Chiara
AU - Petrone, Marcella
AU - Rinaldi, Marilisa
AU - RILEY, GRAHAM J.
AU - Terreni, Silvia
AU - Wood, Martyn
PY - 2006
DA - 2006/08/01
PB - Elsevier
SP - 3906-3912
IS - 15
VL - 16
PMID - 16730983
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{2006_Micheli,
author = {Fabrizio Micheli and Alessandra Pasquarello and Giovanna Tedesco and Dieter Hamprecht and Giorgio Bonanomi and Anna Checchia and Albert Jaxa-Chamiec and Federica Damiani and Silvia Davalli and Daniele Donati and Chiara Gallotti and Marcella Petrone and Marilisa Rinaldi and GRAHAM J. RILEY and Silvia Terreni and Martyn Wood},
title = {Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2006},
volume = {16},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2006.05.034},
number = {15},
pages = {3906--3912},
doi = {10.1016/j.bmcl.2006.05.034}
}
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MLA
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Micheli, Fabrizio, et al. “Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation.” Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 15, Aug. 2006, pp. 3906-3912. https://doi.org/10.1016/j.bmcl.2006.05.034.