Synthesis and cytotoxic activities of 4,5-diarylisoxazoles
Changming Sun
1
,
Lee-Gin Lin
2
,
Hsi Jung Yu
2
,
Chih-Yu Cheng
2
,
Ya Chuan Tsai
2
,
Chi-Wei Chu
1
,
Yi Hui Din
1
,
Yat-Pang Chau
3
,
Ming-Jaw Don
2
Publication type: Journal Article
Publication date: 2007-02-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
17127061
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.
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42
Total citations:
42
Citations from 2025:
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BibTex |
MLA
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GOST
Copy
Sun C. et al. Synthesis and cytotoxic activities of 4,5-diarylisoxazoles // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 4. pp. 1078-1081.
GOST all authors (up to 50)
Copy
Sun C., Lin L., Yu H. J., Cheng C., Tsai Ya. C., Chu C., Din Y. H., Chau Y., Don M. Synthesis and cytotoxic activities of 4,5-diarylisoxazoles // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 4. pp. 1078-1081.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2006.11.023
UR - https://doi.org/10.1016/j.bmcl.2006.11.023
TI - Synthesis and cytotoxic activities of 4,5-diarylisoxazoles
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Sun, Changming
AU - Lin, Lee-Gin
AU - Yu, Hsi Jung
AU - Cheng, Chih-Yu
AU - Tsai, Ya Chuan
AU - Chu, Chi-Wei
AU - Din, Yi Hui
AU - Chau, Yat-Pang
AU - Don, Ming-Jaw
PY - 2007
DA - 2007/02/01
PB - Elsevier
SP - 1078-1081
IS - 4
VL - 17
PMID - 17127061
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Sun,
author = {Changming Sun and Lee-Gin Lin and Hsi Jung Yu and Chih-Yu Cheng and Ya Chuan Tsai and Chi-Wei Chu and Yi Hui Din and Yat-Pang Chau and Ming-Jaw Don},
title = {Synthesis and cytotoxic activities of 4,5-diarylisoxazoles},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2007},
volume = {17},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmcl.2006.11.023},
number = {4},
pages = {1078--1081},
doi = {10.1016/j.bmcl.2006.11.023}
}
Cite this
MLA
Copy
Sun, Changming, et al. “Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.” Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 4, Feb. 2007, pp. 1078-1081. https://doi.org/10.1016/j.bmcl.2006.11.023.