Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability
Тип публикации: Journal Article
Дата публикации: 2007-02-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
17169560
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A series of benzimidazole-based inhibitors of respiratory syncytial virus (RSV) fusion were optimized for antiviral potency, membrane permeability and metabolic stability in human liver microsomes. 1-Cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl]-2H-imidazo[4,5-c]pyridin-2-one (6m, BMS-433771) was identified as a potent RSV inhibitor demonstrating good bioavailability in the mouse, rat, dog and cynomolgus monkey that demonstrated antiviral activity in the BALB/c and cotton rat models of infection following oral administration.
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MLA
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ГОСТ
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Yu K. et al. Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 4. pp. 895-901.
ГОСТ со всеми авторами (до 50)
Скопировать
Yu K., Sin N., Civiello R. L., Wang X., Combrink K. D., Gülgeze H. B., Venables B. L., Wright J. J. K., Dalterio R. A., Zadjura L., Marino A. R., Dando S., D'Arienzo C., Kadow K. F., Cianci C. W., Li Z., Clarke J., Genovesi E. V., Medina I., Lamb L., Colonno R. J., Zheng Y., Krystal M., Meanwell N. A. Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 4. pp. 895-901.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2006.11.063
UR - https://doi.org/10.1016/j.bmcl.2006.11.063
TI - Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Yu, Kuo-Long
AU - Sin, Ny
AU - Civiello, Rita L.
AU - Wang, Xiongfei
AU - Combrink, Keith D.
AU - Gülgeze, H Belgin
AU - Venables, Brian L.
AU - Wright, J J Kim
AU - Dalterio, Richard A
AU - Zadjura, Lisa
AU - Marino, Anthony R.
AU - Dando, Sandra
AU - D'Arienzo, Celia
AU - Kadow, Kathleen F.
AU - Cianci, Christopher W.
AU - Li, Zhufang
AU - Clarke, Junius
AU - Genovesi, Eugene V.
AU - Medina, Ivette
AU - Lamb, Lucinda
AU - Colonno, Richard J.
AU - Zheng, Yang
AU - Krystal, Mark
AU - Meanwell, Nicholas A.
PY - 2007
DA - 2007/02/01
PB - Elsevier
SP - 895-901
IS - 4
VL - 17
PMID - 17169560
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{2007_Yu,
author = {Kuo-Long Yu and Ny Sin and Rita L. Civiello and Xiongfei Wang and Keith D. Combrink and H Belgin Gülgeze and Brian L. Venables and J J Kim Wright and Richard A Dalterio and Lisa Zadjura and Anthony R. Marino and Sandra Dando and Celia D'Arienzo and Kathleen F. Kadow and Christopher W. Cianci and Zhufang Li and Junius Clarke and Eugene V. Genovesi and Ivette Medina and Lucinda Lamb and Richard J. Colonno and Yang Zheng and Mark Krystal and Nicholas A. Meanwell},
title = {Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2007},
volume = {17},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmcl.2006.11.063},
number = {4},
pages = {895--901},
doi = {10.1016/j.bmcl.2006.11.063}
}
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MLA
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Yu., Kuo-Long, et al. “Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability.” Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 4, Feb. 2007, pp. 895-901. https://doi.org/10.1016/j.bmcl.2006.11.063.