том 17 издание 7 страницы 2091-2095

Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives

Тип публикацииJournal Article
Дата публикации2007-04-01
scimago Q2
wos Q2
БС2
SJR0.472
CiteScore5.1
Impact factor2.2
ISSN0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC(50) values of 0.17 and 0.29 microM and TI values of 466.9 and 354.5, respectively.
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ГОСТ |
Цитировать
Chen S. et al. Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 7. pp. 2091-2095.
ГОСТ со всеми авторами (до 50) Скопировать
Chen S., Wang Y., Jin Y., Tian X., Zheng Y., LUO D., Tu Y. Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives // Bioorganic and Medicinal Chemistry Letters. 2007. Vol. 17. No. 7. pp. 2091-2095.
RIS |
Цитировать
TY - JOUR
DO - 10.1016/j.bmcl.2006.11.070
UR - https://doi.org/10.1016/j.bmcl.2006.11.070
TI - Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Chen, Shi-Wu
AU - Wang, Y
AU - Jin, Yan
AU - Tian, Xuan
AU - Zheng, Yong-Tang
AU - LUO, DU-QIANG
AU - Tu, Yong-Qiang
PY - 2007
DA - 2007/04/01
PB - Elsevier
SP - 2091-2095
IS - 7
VL - 17
PMID - 17317161
SN - 0960-894X
SN - 1464-3405
ER -
BibTex |
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BibTex (до 50 авторов) Скопировать
@article{2007_Chen,
author = {Shi-Wu Chen and Y Wang and Yan Jin and Xuan Tian and Yong-Tang Zheng and DU-QIANG LUO and Yong-Qiang Tu},
title = {Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2007},
volume = {17},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.bmcl.2006.11.070},
number = {7},
pages = {2091--2095},
doi = {10.1016/j.bmcl.2006.11.070}
}
MLA
Цитировать
Chen, Shi-Wu, et al. “Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives.” Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 7, Apr. 2007, pp. 2091-2095. https://doi.org/10.1016/j.bmcl.2006.11.070.