Bioorganic and Medicinal Chemistry Letters

, volume 24 , issue 14 , pages 3175-3179

Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases

Oleksandr Kobzar ¹

Viacheslav V Trush ¹

Vsevolod Yu Tanchuk ¹

Alexander V Zhilenkov ²

Pavel A. Troshin ²

Andriy Vovk ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska 1, 02660 Kyiv-94, Ukraine |

Institute for Problems of Chemical Physics of Russian Academy of Sciences, Semenov Prospect 1, Chernogolovka, Moscow region 142432, Russia |

Publication type: Journal Article

Publication date: 2014-07-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2014.04.110

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PubMed ID: 24856066

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

In this study, we identified water-soluble C60 and C70 fullerene derivatives as a novel class of protein tyrosine phosphatase inhibitors. The evaluated compounds were found to inhibit CD45, PTP1B, TC-PTP, SHP2, and PTPβ with IC50 values in the low micromolar to high nanomolar range. These results demonstrate a new strategy for designing effective nanoscale protein tyrosine phosphatase inhibitors.

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Kraevaya Olga

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PhD in Chemistry

72 publications, 461 citations, 11 reviews

h-index: 12

Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS

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GOST Copy

Kobzar O. et al. Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 14. pp. 3175-3179.

GOST all authors (up to 50) Copy

Kobzar O., Trush V. V., Tanchuk V. Yu., Zhilenkov A. V., Troshin P. A., Vovk A. Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 14. pp. 3175-3179.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.bmcl.2014.04.110

UR - https://doi.org/10.1016/j.bmcl.2014.04.110

TI - Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Kobzar, Oleksandr

AU - Trush, Viacheslav V

AU - Tanchuk, Vsevolod Yu

AU - Zhilenkov, Alexander V

AU - Troshin, Pavel A.

AU - Vovk, Andriy

PY - 2014

DA - 2014/07/01

PB - Elsevier

SP - 3175-3179

IS - 14

VL - 24

PMID - 24856066

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2014_Kobzar,

author = {Oleksandr Kobzar and Viacheslav V Trush and Vsevolod Yu Tanchuk and Alexander V Zhilenkov and Pavel A. Troshin and Andriy Vovk},

title = {Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2014},

volume = {24},

publisher = {Elsevier},

month = {jul},

url = {https://doi.org/10.1016/j.bmcl.2014.04.110},

number = {14},

pages = {3175--3179},

doi = {10.1016/j.bmcl.2014.04.110}

}

MLA

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MLA Copy

Kobzar, Oleksandr, et al. “Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases.” Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 14, Jul. 2014, pp. 3175-3179. https://doi.org/10.1016/j.bmcl.2014.04.110.