Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents
Тип публикации: Journal Article
Дата публикации: 2014-07-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
24878196
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A series of amides were synthesized by condensation of theophylline-7-acetic acid and eight commercially available amino acid methyl ester hydrochlorides. Consecutive hydrolysis of six of the amido-esters resulted in the formation of corresponding amido-acids. The newly synthesized compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv. The activity varied depending on the amino acid fragments and in seven cases exerted excellent values with MICs 0.46-0.26 μM. Assessment of the cytotoxicity revealed that the compounds were not cytotoxic against the human embryonal kidney cell line HEK-293T. The theophylline-7-acetamides containing amino acid moieties appear to be promising lead compounds for the development of antimycobacterial agents.
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ГОСТ
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Voynikov Y. et al. Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 14. pp. 3043-3045.
ГОСТ со всеми авторами (до 50)
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Voynikov Y., Valcheva V. V., Momekov G., Peikov P., Stavrakov G. Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 14. pp. 3043-3045.
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TY - JOUR
DO - 10.1016/j.bmcl.2014.05.026
UR - https://doi.org/10.1016/j.bmcl.2014.05.026
TI - Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Voynikov, Yulian
AU - Valcheva, Violeta V.
AU - Momekov, Georgi
AU - Peikov, Plamen
AU - Stavrakov, Georgi
PY - 2014
DA - 2014/07/01
PB - Elsevier
SP - 3043-3045
IS - 14
VL - 24
PMID - 24878196
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{2014_Voynikov,
author = {Yulian Voynikov and Violeta V. Valcheva and Georgi Momekov and Plamen Peikov and Georgi Stavrakov},
title = {Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2014},
volume = {24},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.bmcl.2014.05.026},
number = {14},
pages = {3043--3045},
doi = {10.1016/j.bmcl.2014.05.026}
}
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MLA
Скопировать
Voynikov, Yulian, et al. “Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents.” Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 14, Jul. 2014, pp. 3043-3045. https://doi.org/10.1016/j.bmcl.2014.05.026.