Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity
Publication type: Journal Article
Publication date: 2014-08-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
24951329
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
The synthesis and biological evaluation of a novel pyridinium salt is reported. Initial membrane interaction with isolated phospholipid monolayers was obtained with the pyridinium salt, and two neutral analogues for comparison, and the anticancer effects of the best compound established using a cytotoxicity screening assay against glioma cells using both an established cell line and three short-term cell cultures-one of which has been largely resistant to all chemotherapeutic drugs tested to date. The results indicate that the pyridinium salt exhibits potent anticancer activity (EC50s=9.8-312.5 μM) on all cell types, including the resistant one, for a continuous treatment of 72 h. Microscopic examination of the treated cells using a trypan blue exclusion assay showed membrane lysis had occurred. Therefore, this letter highlights the potential for a new class of pyridinium salt to be developed as a much needed alternative treatment for glioma chemotherapy.
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Total citations:
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Citations from 2025:
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(14.29%)
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GOST
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Fahs S. et al. Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 15. pp. 3430-3433.
GOST all authors (up to 50)
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Fahs S., Rowther F. B., Dennison S., Patil-Sen Y., Warr T., Snape T. J. Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 15. pp. 3430-3433.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2014.05.087
UR - https://doi.org/10.1016/j.bmcl.2014.05.087
TI - Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Fahs, Sara
AU - Rowther, Farjana B.
AU - Dennison, Sarah
AU - Patil-Sen, Yogita
AU - Warr, Tracy
AU - Snape, Timothy J
PY - 2014
DA - 2014/08/01
PB - Elsevier
SP - 3430-3433
IS - 15
VL - 24
PMID - 24951329
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Fahs,
author = {Sara Fahs and Farjana B. Rowther and Sarah Dennison and Yogita Patil-Sen and Tracy Warr and Timothy J Snape},
title = {Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2014},
volume = {24},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2014.05.087},
number = {15},
pages = {3430--3433},
doi = {10.1016/j.bmcl.2014.05.087}
}
Cite this
MLA
Copy
Fahs, Sara, et al. “Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity.” Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 15, Aug. 2014, pp. 3430-3433. https://doi.org/10.1016/j.bmcl.2014.05.087.