Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay
Marina Semenova
1
,
Dmitry V Tsyganov
2
,
Oleg R Malyshev
2
,
О.В. Ершов
3
,
Ivan N. Bardasov
3
,
Roman V Semenov
2
,
Alex S Kiselyov
4
,
Victor Semenov
5
2
5
Chemical Block Ltd, 3 Kyriacou Matsi, 3723 Limassol, Cyprus
|
Publication type: Journal Article
Publication date: 2014-08-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
24997684
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of polyalkoxy substituted 7-hydroxy- and 7-methoxy-4-aryl-4 H -chromenes were evaluated using the sea urchin embryo model to yield several compounds exhibiting potent antimitotic microtubule destabilizing activity. Data obtained by the assay were further confirmed in the NCI60 human cancer cell screen. The replacement of methylenedioxy ring A and lactone ring D in podophyllotoxin analogues by 7-methoxy, 2-NH 2 , and 3-CN groups in 4-aryl-4 H -chromenes resulted in potent antimitotic microtubule destabilizing agents. Feasible synthesis and high yields render 7-methoxy-4 H -chromenes to be a promising series for further anticancer drug development.
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GOST
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Semenova M. et al. Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 16. pp. 3914-3918.
GOST all authors (up to 50)
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Semenova M., Tsyganov D. V., Malyshev O. R., Ершов О., Bardasov I. N., Semenov R. V., Kiselyov A. S., Semenov V. Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 16. pp. 3914-3918.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2014.06.043
UR - https://doi.org/10.1016/j.bmcl.2014.06.043
TI - Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Semenova, Marina
AU - Tsyganov, Dmitry V
AU - Malyshev, Oleg R
AU - Ершов, О.В.
AU - Bardasov, Ivan N.
AU - Semenov, Roman V
AU - Kiselyov, Alex S
AU - Semenov, Victor
PY - 2014
DA - 2014/08/01
PB - Elsevier
SP - 3914-3918
IS - 16
VL - 24
PMID - 24997684
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Semenova,
author = {Marina Semenova and Dmitry V Tsyganov and Oleg R Malyshev and О.В. Ершов and Ivan N. Bardasov and Roman V Semenov and Alex S Kiselyov and Victor Semenov},
title = {Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2014},
volume = {24},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2014.06.043},
number = {16},
pages = {3914--3918},
doi = {10.1016/j.bmcl.2014.06.043}
}
Cite this
MLA
Copy
Semenova, Marina, et al. “Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.” Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 16, Aug. 2014, pp. 3914-3918. https://doi.org/10.1016/j.bmcl.2014.06.043.