Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates
Тип публикации: Journal Article
Дата публикации: 2014-11-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
25442310
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
Betulinic acid and analogous naturally occurring triterpenoid acids were transformed into the corresponding propargyl esters and subsequently deployed as substrates for a click chemistry-mediated coupling with azidothymidine (AZT) en route to novel 1,2,3-triazole-tethered triterpenoid-AZT conjugates. Twelve new hybrids were thus prepared and assessed in terms of their cytotoxic activity, revealing an interesting anticancer activity of five triterpenoid-AZT hybrids on KB and Hep-G2 tumor cell lines.
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Dang T. T. A. et al. Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 22. pp. 5190-5194.
ГОСТ со всеми авторами (до 50)
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Dang T. T. A., Kim Tuyet N. T., Pham The C., Thanh Nguyen H., Cham B. T., Doan D. T., D'hooghe M., Van Nguyen T. Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 22. pp. 5190-5194.
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TY - JOUR
DO - 10.1016/j.bmcl.2014.09.079
UR - https://doi.org/10.1016/j.bmcl.2014.09.079
TI - Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Dang, Thi Tuyet Anh
AU - Kim Tuyet, Nguyen Thi
AU - Pham The, Chinh
AU - Thanh Nguyen, Ha
AU - Cham, Ba Thi
AU - Doan, Duy Tien
AU - D'hooghe, Matthias
AU - Van Nguyen, Tuyen
PY - 2014
DA - 2014/11/01
PB - Elsevier
SP - 5190-5194
IS - 22
VL - 24
PMID - 25442310
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2014_Dang,
author = {Thi Tuyet Anh Dang and Nguyen Thi Kim Tuyet and Chinh Pham The and Ha Thanh Nguyen and Ba Thi Cham and Duy Tien Doan and Matthias D'hooghe and Tuyen Van Nguyen},
title = {Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2014},
volume = {24},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.bmcl.2014.09.079},
number = {22},
pages = {5190--5194},
doi = {10.1016/j.bmcl.2014.09.079}
}
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MLA
Скопировать
Dang, Thi Tuyet Anh, et al. “Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates.” Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 22, Nov. 2014, pp. 5190-5194. https://doi.org/10.1016/j.bmcl.2014.09.079.