2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists
Тип публикации: Journal Article
Дата публикации: 2014-12-01
SCImago Q2
WOS Q2
БС2
SJR: 0.426
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
25455491
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
2-Aminopyrimidin-4(1 H )-one was proposed as the novel bioisostere of urea. Bioisosteric replacement of the reported urea series of the CXCR2 antagonists with 2-aminopyrimidin-4(1 H )-ones led to the discovery of the novel and potent CXCR2 antagonist 3e . 2-Aminopyrimidin-4(1 H )-one derivative 3e demonstrated a good developability profile (reasonable solubility and high permeability) and superior chemical stability especially in simulated gastric fluid (SGF) compared with ureas.
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ГОСТ
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Lu H. et al. 2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 23. pp. 5493-5496.
ГОСТ со всеми авторами (до 50)
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Lu H., Yang T., Xu Z., Wren P., Zhang Y., Cai X., Patel M., Dong K., Zhang Q., Zhang W. G., Guan X., Xiang J., Elliott J. F., Lin X., Ren F. 2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists // Bioorganic and Medicinal Chemistry Letters. 2014. Vol. 24. No. 23. pp. 5493-5496.
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TY - JOUR
DO - 10.1016/j.bmcl.2014.10.003
UR - https://doi.org/10.1016/j.bmcl.2014.10.003
TI - 2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Lu, Hongfu
AU - Yang, Ting
AU - Xu, Zhongmiao
AU - Wren, Paul B.
AU - Zhang, Yueting
AU - Cai, Xin
AU - Patel, Metul
AU - Dong, Kelly
AU - Zhang, Qinghua
AU - Zhang, Wei Guo
AU - Guan, Xiao-Ming
AU - Xiang, Jianing
AU - Elliott, John F.
AU - Lin, Xichen
AU - Ren, Fangfang
PY - 2014
DA - 2014/12/01
PB - Elsevier
SP - 5493-5496
IS - 23
VL - 24
PMID - 25455491
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (до 50 авторов)
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@article{2014_Lu,
author = {Hongfu Lu and Ting Yang and Zhongmiao Xu and Paul B. Wren and Yueting Zhang and Xin Cai and Metul Patel and Kelly Dong and Qinghua Zhang and Wei Guo Zhang and Xiao-Ming Guan and Jianing Xiang and John F. Elliott and Xichen Lin and Fangfang Ren},
title = {2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2014},
volume = {24},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.bmcl.2014.10.003},
number = {23},
pages = {5493--5496},
doi = {10.1016/j.bmcl.2014.10.003}
}
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MLA
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Lu, Hongfu, et al. “2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists.” Bioorganic and Medicinal Chemistry Letters, vol. 24, no. 23, Dec. 2014, pp. 5493-5496. https://doi.org/10.1016/j.bmcl.2014.10.003.
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