Enediynes: Exploration of microbial genomics to discover new anticancer drug leads
Ben Shen
1
,
Hindra
2
,
Xiaohui Yan
2
,
Tingting Huang
2
,
HUI GE
2
,
Dong Sik Yang
2
,
Qihui Teng
2
,
Jeffrey D Rudolf
2
,
Jeremy R. Lohman
2
Тип публикации: Journal Article
Дата публикации: 2015-01-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
25434000
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
The enediyne natural products have been explored for their phenomenal cytotoxicity. The development of enediynes into anticancer drugs has been successfully achieved through the utilization of polymer- and antibody-drug conjugates (ADCs) as drug delivery systems. An increasing inventory of enediynes would benefit current application of ADCs in many oncology programs. Innovations in expanding the enediyne inventory should take advantage of the current knowledge of enediyne biosynthesis and post-genomics technologies. Bioinformatics analysis of microbial genomes reveals that enediynes are underexplored, in particular from Actinomycetales. This digest highlights the emerging opportunities to explore microbial genomics for the discovery of novel enediyne natural products.
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ГОСТ
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Shen B. et al. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 1. pp. 9-15.
ГОСТ со всеми авторами (до 50)
Скопировать
Shen B., Hindra, Yan X., Huang T., GE H., Yang D. S., Teng Q., Rudolf J. D., Lohman J. R. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 1. pp. 9-15.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2014.11.019
UR - https://doi.org/10.1016/j.bmcl.2014.11.019
TI - Enediynes: Exploration of microbial genomics to discover new anticancer drug leads
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Shen, Ben
AU - Hindra
AU - Yan, Xiaohui
AU - Huang, Tingting
AU - GE, HUI
AU - Yang, Dong Sik
AU - Teng, Qihui
AU - Rudolf, Jeffrey D
AU - Lohman, Jeremy R.
PY - 2015
DA - 2015/01/01
PB - Elsevier
SP - 9-15
IS - 1
VL - 25
PMID - 25434000
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2015_Shen,
author = {Ben Shen and Hindra and Xiaohui Yan and Tingting Huang and HUI GE and Dong Sik Yang and Qihui Teng and Jeffrey D Rudolf and Jeremy R. Lohman},
title = {Enediynes: Exploration of microbial genomics to discover new anticancer drug leads},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2015},
volume = {25},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.bmcl.2014.11.019},
number = {1},
pages = {9--15},
doi = {10.1016/j.bmcl.2014.11.019}
}
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MLA
Скопировать
Shen, Ben, et al. “Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.” Bioorganic and Medicinal Chemistry Letters, vol. 25, no. 1, Jan. 2015, pp. 9-15. https://doi.org/10.1016/j.bmcl.2014.11.019.