Bioorganic and Medicinal Chemistry Letters

, volume 26 , issue 16 , pages 3955-3957

Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

Germán F Giri ¹

Mauro Danielli ²

Raúl A Marinelli ²

Rolando A. Spanevello ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Instituto de Química de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario - CONICET, Suipacha 531, S2002LRK, Rosario, Argentina. |

Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario-CONICET, Suipacha 531, S2002LRK Rosario, Argentina. |

Publication type: Journal Article

Publication date: 2016-08-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2016.07.007

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PubMed ID: 27422336

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50 values of cisplatin, a frequently administered chemotherapy drug.

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GOST |

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GOST Copy

Giri G. F. et al. Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines // Bioorganic and Medicinal Chemistry Letters. 2016. Vol. 26. No. 16. pp. 3955-3957.

GOST all authors (up to 50) Copy

Giri G. F., Danielli M., Marinelli R. A., Spanevello R. A. Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines // Bioorganic and Medicinal Chemistry Letters. 2016. Vol. 26. No. 16. pp. 3955-3957.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.bmcl.2016.07.007

UR - https://doi.org/10.1016/j.bmcl.2016.07.007

TI - Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Giri, Germán F

AU - Danielli, Mauro

AU - Marinelli, Raúl A

AU - Spanevello, Rolando A.

PY - 2016

DA - 2016/08/01

PB - Elsevier

SP - 3955-3957

IS - 16

VL - 26

PMID - 27422336

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2016_Giri,

author = {Germán F Giri and Mauro Danielli and Raúl A Marinelli and Rolando A. Spanevello},

title = {Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2016},

volume = {26},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/j.bmcl.2016.07.007},

number = {16},

pages = {3955--3957},

doi = {10.1016/j.bmcl.2016.07.007}

}

MLA

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MLA Copy

Giri, Germán F., et al. “Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines.” Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 16, Aug. 2016, pp. 3955-3957. https://doi.org/10.1016/j.bmcl.2016.07.007.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)