Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
Тип публикации: Journal Article
Дата публикации: 2018-11-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
30201293
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
In order to enhance the mitochondria-targeting ability of spinosad. A series of quartenary ammonium spinosyn derivatives was designed and synthesized. Some of the derivatives displayed greatly enhanced antiproliferative ability towards tested human cancer cell lines. The structure activity relationship study indicated that lipophilicity has a great influence on the antiproliferative effects of these derivatives. The most active compound 11d exhibited remarkably enhanced OXPHS inhibition and apoptosis inducing ability than spinosyn A.
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Ma D. et al. Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives. // Bioorganic and Medicinal Chemistry Letters. 2018. Vol. 28. No. 20. pp. 3346-3349.
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Ma D., Wang L., Lai Q., Peng K., Li X., LI Z., Liu L. J., Luo Z., Liu S. Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives. // Bioorganic and Medicinal Chemistry Letters. 2018. Vol. 28. No. 20. pp. 3346-3349.
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TY - JOUR
DO - 10.1016/j.bmcl.2018.09.005
UR - https://doi.org/10.1016/j.bmcl.2018.09.005
TI - Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Ma, Da-You
AU - Wang, Long-Long
AU - Lai, Qin
AU - Peng, Kun-Jian
AU - Li, Xuan
AU - LI, ZENG-XIA
AU - Liu, Li Jun
AU - Luo, Zhi-yong
AU - Liu, Suyou
PY - 2018
DA - 2018/11/01
PB - Elsevier
SP - 3346-3349
IS - 20
VL - 28
PMID - 30201293
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2018_Ma,
author = {Da-You Ma and Long-Long Wang and Qin Lai and Kun-Jian Peng and Xuan Li and ZENG-XIA LI and Li Jun Liu and Zhi-yong Luo and Suyou Liu},
title = {Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2018},
volume = {28},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.bmcl.2018.09.005},
number = {20},
pages = {3346--3349},
doi = {10.1016/j.bmcl.2018.09.005}
}
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Ma, Da-You, et al. “Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives..” Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 20, Nov. 2018, pp. 3346-3349. https://doi.org/10.1016/j.bmcl.2018.09.005.